3-(1-chloroH-pyrrolo[1,2-a]pyrazin-6-yl)cyclobutanone

Base Information

• Chemical Name: 3-(1-chloroH-pyrrolo[1,2-a]pyrazin-6-yl)cyclobutanone
• CAS No.: 936901-72-3
• Molecular Formula: C10H8ClN3O
• Molecular Weight: 221.64
• Mol file: 936901-72-3.mol

Synonyms:3-(8-CHLOROIMIDAZO[1,5-A]PYRAZIN-3-YL)CYCLOBUTANONE;

Chemical Property of 3-(1-chloroH-pyrrolo[1,2-a]pyrazin-6-yl)cyclobutanone

Chemical Property:

• PKA: 3.30±0.30(Predicted)
• PSA: 47.26000
• Density: 1 +-.0.1 g/cm3(Predicted)
• LogP: 1.82920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(8-Chloroimidazo[1,5-a]pyrazin-3-yl)cyclobutanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1-chloroH-pyrrolo[1,2-a]pyrazin-6-yl)cyclobutanone

There total 5 articles about 3-(1-chloroH-pyrrolo[1,2-a]pyrazin-6-yl)cyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(2-chlorophenyl(methyl))]-3-oxocyclobutanecarboxamide (939412-84-7) → 3-(8-chloroimidazo[1,5-a]pyrazin-3-yl)cyclobutanone (936901-72-3)

Guidance literature:

N-[(2-chlorophenyl(methyl))]-3-oxocyclobutanecarboxamide; With N,N-dimethyl-formamide; trichlorophosphate; In ethyl acetate; for 2h;

With sodium carbonate; In water; ethyl acetate;

Reference yield:

3-oxocyclobutanecarboxylic acid 2,5-dioxopyrrolidin-1-yl ester (939412-81-4) + C-(3-chloropyrazin-2-yl)-methylamine hydrochloride salt (939412-86-9,867165-53-5) → 3-(8-chloroimidazo[1,5-a]pyrazin-3-yl)cyclobutanone (936901-72-3)

Guidance literature:

3-oxocyclobutanecarboxylic acid 2,5-dioxopyrrolidin-1-yl ester; C-(3-chloropyrazin-2-yl)-methylamine hydrochloride salt; With sodium hydrogencarbonate; In tetrahydrofuran; for 0.333333h;

With trichlorophosphate; In ethyl acetate; N,N-dimethyl-formamide; at 10.5 ℃; for 1h;

With sodium carbonate; In water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

C14H13ClN4O4 → 3-(8-chloroimidazo[1,5-a]pyrazin-3-yl)cyclobutanone (936901-72-3)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 10 - 20 ℃; for 0.75h;

DOI:10.1021/ml400160a

upstream raw materials:

3-oxocyclobutanecarboxylic acid 2,5-dioxopyrrolidin-1-yl ester

C-(3-chloropyrazin-2-yl)-methylamine hydrochloride salt

N-[(2-chlorophenyl(methyl))]-3-oxocyclobutanecarboxamide

3-oxocyclobutanecarboxylic acid

Refernces

• 1、 -. "PROTEIN KINASE INHIBITORS". Page/Page column 57; 58. . Retrieved 2015/06/08.
• 2、 -. "Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors". Page/Page column 58. . Retrieved 2010/11/29.