5-(2-(5,6-Diethylindan-2-ylamino)-1-hydroxyethyl)-8-hydroxy-1H-quinolin-2-one

Base Information

• Chemical Name: 5-(2-(5,6-Diethylindan-2-ylamino)-1-hydroxyethyl)-8-hydroxy-1H-quinolin-2-one
• CAS No.: 889852-02-2
• Molecular Formula: C24H28N2O3
• Molecular Weight: 704.538
• Mol file: 889852-02-2.mol

Synonyms:Poly(phthalidylidene-p-phenyleneoxyterephthaloyloxy-p-phenylene); 1,4-Benzenedicarboxylic acid-4,4'-phthalidylidenediphenol copolymer,SRU; F 2; F 2 (polyester); FV 2; FV 2 (polyester); Phenolphthalein-terephthalicacid copolymer, SRU; Phenolphthalein-terephthalic acid dichloride copolymer,SRU; Phenolphthalein-terephthaloyl chloride copolymer, SRU; Phenolphthalein-terephthaloyl dichloride copolymer, SRU; Phthalidylidenediphenol-terephthalic acid copolymer, sru; Terephthaloylchloride-phenolphthalein copolymer, sru; F-2

Chemical Property of 5-(2-(5,6-Diethylindan-2-ylamino)-1-hydroxyethyl)-8-hydroxy-1H-quinolin-2-one

Chemical Property:

• PSA: 128.72000
• LogP: 6.52870

Purity/Quality:

98%min ^*data from raw suppliers

MonobenzylFosaprepitant ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Monobenzyl Fosaprepitant is an impurity of Fosaprepitant (F727300), a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.

Technology Process of 5-(2-(5,6-Diethylindan-2-ylamino)-1-hydroxyethyl)-8-hydroxy-1H-quinolin-2-one

There total 4 articles about 5-(2-(5,6-Diethylindan-2-ylamino)-1-hydroxyethyl)-8-hydroxy-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.8%

[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid bis(phenylmethyl)ester (265121-01-5) → benzyloxy (3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphinic acid (889852-02-2)

Guidance literature:

With methanol; at 40 - 50 ℃; for 8h;

Reference yield: 76.0%

dibenzyl phosphochloridate (538-37-4) + aprepitant → benzyloxy (3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphinic acid (889852-02-2)

Guidance literature:

aprepitant; With sodium hexamethyldisilazane; In tetrahydrofuran; at 5 ℃; for 0.25h; Inert atmosphere; Industrial scale;

dibenzyl phosphochloridate; In tetrahydrofuran; at 5 ℃; for 0.166667h; Inert atmosphere; Industrial scale;

With methanol; In tetrahydrofuran; at 45 ℃; for 20h; Concentration; Inert atmosphere; Industrial scale;

Reference yield: 75.0%

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate (990-91-0) + aprepitant → benzyloxy (3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphinic acid (889852-02-2)

Guidance literature:

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate; aprepitant; In tetrahydrofuran; at -5 - 0 ℃; for 0.166667h; Inert atmosphere; Industrial scale;

With methanol; In tetrahydrofuran; at 45 ℃; for 0.5h; Inert atmosphere; Industrial scale;

upstream raw materials:

methanol

[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid bis(phenylmethyl)ester

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

dibenzyl phosphochloridate

Downstream raw materials:

{3-[[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid N-methyl-L-glucamine salt

Refernces

• 1、 -. "A process for the preparation of [3 - [(2 R) - [(1 R) - 1 - [3, 5 - di (trifluoromethyl) phenyl] ethoxy] - 3 (S)- (4 - fluorophenyl) morpholine - 4 - yl] methyl] - 5 - oxo - 4, 5 - dihydro - [1, 2, 4] - triazole - 1 - yl] phosphine acid animal pen ester new method". Paragraph 0049; 0052-0053. . Retrieved 2017/08/26.