Tricyclo[3.3.1.13,7]decan-1-amine, 3,5,7-trimethyl-, hydrochloride

Base Information

• Chemical Name: Tricyclo[3.3.1.13,7]decan-1-amine, 3,5,7-trimethyl-, hydrochloride
• CAS No.: 15210-60-3
• Molecular Formula: C13H23N^.HCl
• Molecular Weight: 229.79
• Hs Code.: 2921300000
• Mol file: 15210-60-3.mol

Synonyms:3,5,7-Trimethyl-1-adamantanamine hydrochloride (1:1);

Chemical Property of Tricyclo[3.3.1.13,7]decan-1-amine, 3,5,7-trimethyl-, hydrochloride

Chemical Property:

• Boiling Point: 272.5 °C at 760 mmHg
• Flash Point: 118.6 °C
• PSA: 26.02000
• LogP: 4.58650
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

7-MethylMemantineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Methyl Memantine is an impurity of Memantine (HCl salt, M218000) which is used as an antiparkinsonian and antispasmodic.

Technology Process of Tricyclo[3.3.1.13,7]decan-1-amine, 3,5,7-trimethyl-, hydrochloride

There total 7 articles about Tricyclo[3.3.1.13,7]decan-1-amine, 3,5,7-trimethyl-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-3,5,7-trimethyladamantane (53398-55-3) → 3,5,7-trimethyl-1-aminoadamantane hydrochloride (15210-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: phosphoric acid / 17.5 h / 20 - 87 °C

1.2: 20 - 45 °C / pH 6 - 7

2.1: potassium hydroxide; butan-1-ol / 15.33 - 15.5 h / 20 - 132 °C

2.2: 0.33 h / 20 - 50 °C / pH 1

With potassium hydroxide; phosphoric acid; butan-1-ol;

Reference yield:

1,3,5-trimethyladamantane (707-35-7) → 3,5,7-trimethyl-1-aminoadamantane hydrochloride (15210-60-3)

Guidance literature:

Multi-step reaction with 5 steps

1: nitric acid / acetic acid

2: acetic acid / 90 °C

3: acetic acid; nitric acid / 90 °C

4: sodium hydroxide

5: hydrogenchloride

With hydrogenchloride; nitric acid; acetic acid; sodium hydroxide; In acetic acid;

DOI:10.1134/S1070428015120064

Reference yield:

N-acetyl-3,5,7-trimethyl-1-aminoadamantane (15210-64-7) → 3,5,7-trimethyl-1-aminoadamantane hydrochloride (15210-60-3)

Guidance literature:

N-acetyl-3,5,7-trimethyl-1-aminoadamantane; With potassium hydroxide; butan-1-ol; at 20 - 132 ℃; for 15.33 - 15.5h;

With hydrogenchloride; In water; at 20 - 50 ℃; for 0.333333h; pH=1;

upstream raw materials:

N-acetyl-3,5,7-trimethyl-1-aminoadamantane

1,3,5-trimethyladamantane

1,3,5-Trimethyl-7-nitrooxy-adamantane

3,5,7-trimethyl-1-adamantanamine

Refernces

• 1、 -. "PROCESS FOR PREPARING MEMANTINE HYDROCHLORIDE SUBSTANTIALLY FREE OF IMPURITIES". Page/Page column 22-23. . Retrieved 2008/06/13.