VitaminK2(35)0.13%Powder

Base Information

• Chemical Name: VitaminK2(35)0.13%Powder
• CAS No.: 27670-94-6
• Molecular Formula: C46H64O2
• Molecular Weight: 649.00
• Mol file: 27670-94-6.mol

Synonyms:VitaminK2(35)0.13%Oil;Vitamin K2(35),MK7 0.13% Oil;Vitamin K2,MK7,menaquinone, menaquinon-7, menatetrenone, menatetren, menatetrenona, menatetrenonum;Vitamin K2(35),MK7 1.3% Oil;Vitamin K2(35),MK7 1.3% Powder;Vitamin K2(35),MK7 0.13% Powder;Vitamin K2(35),MK-7;VitaminK2(35)0.13%Powder

Chemical Property of VitaminK2(35)0.13%Powder

Chemical Property:

• Melting Point: 54oC
• Boiling Point: 200oC at 0.0002 MM HG (SOME DECOMP)
• PSA: 34.14000
• LogP: 14.09740

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of VitaminK2(35)0.13%Powder

There total 70 articles about VitaminK2(35)0.13%Powder which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl)-1,4-dimethoxy-3-methylnaphthalene (1218784-62-3) → menaquinone-7 (2124-57-4,27670-94-6)

Guidance literature:

With ammonium cerium (IV) nitrate; In water; acetonitrile; at 20 ℃; for 4.08333h;

Reference yield: 72.0%

C50H74O2 (1597486-88-8) → menaquinone-7 (2124-57-4,27670-94-6)

Guidance literature:

With ammonium cerium (IV) nitrate; In dichloromethane; water; acetonitrile; at 0 ℃; for 0.25h;

Reference yield: 65.0%

2-(chloromethyl)-3-methylnaphthalene-1,4-dione (31599-79-8) + C33H52 + trimethylaluminum (75-24-1) → menaquinone-7 (2124-57-4,27670-94-6)

Guidance literature:

C₃₃H₅₂; trimethylaluminum; With zirconocene dichloride; In toluene; at 0 ℃; for 1h;

2-(chloromethyl)-3-methylnaphthalene-1,4-dione; With bis(triphenylphosphine)nickel(II) chloride; n-butyllithium; In tetrahydrofuran; hexane; at -20 ℃; for 1h;

upstream raw materials:

(2E,6E)-farnesyl acetate

E,E,E-12-hydroxyfarnesyl acetate

(2E,6E,10E)-3,7,11-trimethyl-12-(phenylsulfonyl)-dodeca-2,6,10-trien-1-yl acetate

farnesyl bromide

Downstream raw materials:

menaquinol

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyl-octacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-diyl dibenzoate

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-diyl bis(4-(trifluoromethyl)benzoate)

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-4-hydroxy-3-methylnaphthalen-1-yl benzoate

Refernces

• 1、 -. "Menaquinol Compositions and Methods of Treatment". Paragraph 0129-0130. . Retrieved 2020/04/09.
• 2、 Baj, Aneta,Wa?ejko, Piotr,Kutner, Andrzej,Kaczmarek, ?ukasz,Morzycki, Jacek W.,Witkowski, Stanis?aw. "Convergent Synthesis of Menaquinone-7 (MK-7)". . p. 1026 - 1033. Retrieved 2016/11/11.