CID 4192180

Base Information

• Chemical Name: CID 4192180
• CAS No.: 14024-97-6
• Molecular Formula: C₁₀H₁₀Cl₂N₂Pt
• Molecular Weight: 424.189
• Mol file: 14024-97-6.mol

Synonyms:CS-0086560

Chemical Property of CID 4192180

Chemical Property:

• Vapor Pressure: 28.3mmHg at 25°C
• Melting Point: 283-286 °C(lit.)
• Boiling Point: 115.3°Cat760mmHg
• Flash Point: 20°C
• PSA: 6.48000
• Density: g/cm³
• LogP: 3.12550
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 422.986898
• Heavy Atom Count: 15
• Complexity: 97.6

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC=C1.C1=CC=NC=C1.Cl[Pt]Cl

Technology Process of CID 4192180

There total 98 articles about CID 4192180 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trans-tetrachlorobis(pyridine)platinum(II) (16893-32-6,17100-03-7,19306-93-5) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → trans-dichlorobis(pyridine)platinum(II) (14024-97-6,14872-21-0,15227-42-6) + (2-methoxy-2-oxoethyl)triphenylphosphonium chloride (2181-97-7) + Triphenylphosphine oxide (791-28-6)

Guidance literature:

In dichloromethane; Ph3P=CHCO2Me was added to soln. Pt(IV) complex in CH2Cl2, react. mixt. was kept at room temp. for 3 h; solvent was evapd., residue was chromed. on silica using CH2Cl2/Et2O (9:1) as eluent;

DOI:10.1021/ic000769c

Reference yield: 95.0%

pyridine (110-86-1) + potassium tetrachloroplatinate → trans-dichlorobis(pyridine)platinum(II) (14024-97-6,14872-21-0,15227-42-6)

Guidance literature:

pyridine; potassium tetrachloroplatinate; In water; for 1h; Heating / reflux;

With hydrogenchloride; In water; at 4 ℃; for 17h;

Reference yield: 92.0%

pyridine (110-86-1) + hydrogenchloride (7647-01-0,15364-23-5) + potassium tetrachloroplatinate(II) (10025-99-7) → trans-dichlorobis(pyridine)platinum(II) (14024-97-6,14872-21-0,15227-42-6)

Guidance literature:

pyridine; potassium tetrachloroplatinate(II); In water; at 85 ℃; for 1.5h;

hydrogenchloride; In water; at 75 ℃;

DOI:10.1039/d1dt01730f

upstream raw materials:

pyridine

thallous 2,3,5,6-tetrafluorobenzoate

Hexafluorobenzene

(SP-4-3)-dichlorido(N,N-dimethyl-ethane-1,2-diamine)platinum(II)

Downstream raw materials:

Pt(P(C₆H₅)2C₁₆H₁₅)2Cl₂*CH₂Cl₂

cis-dichlorobis(dimethylsulfoxide)platinum(II)

cis-[PtCl₂(C₅H₅N)(Me₂SO)]

trans-Pt(Me₂SO)(pyridine)Cl₂

Refernces

• 1、 Miller, Sian E.,Gerard, Kathryn J.,House, Donald A.. "". . p. 135 - 144. Retrieved 1991.
• 2、 Gabano, Elisabetta,Gama, Sofia,Mendes, Filipa,Fregonese, Federico,Paulo, António,Ravera, Mauro. "Application of microwave-assisted heating to the synthesis of Pt(II) complexes". . p. 16 - 19. Retrieved 2015.
• 3、 Annibale, Giuliano,Cattalini, Lucio,Guidi, Francesca. "Acid-Base Equilibria of Co-ordinated Ligands. Part 1. The Effect of Basicity of Co-ordinated Nitrogen Donors upon the Acidity of Chelating 8-Aminoquinoline in some Dicationic Platinum(II) Complexes". . p. 731 - 734. Retrieved 1994.
• 4、 Caricato, Marco,Delforge, Arnaud,Bonifazi, Davide,Dondi, Daniele,Mazzanti, Andrea,Pasini, Dario. "Chiral nanostructuring of multivalent macrocycles in solution and on surfaces". . p. 3593 - 3601. Retrieved 2015.
• 5、 Thompson, Laurence K.. "". . p. 117 - 120. Retrieved 1980.
• 6、 Lewis, Nerissa A.,Pakhomova, Svetlana,Marzilli, Patricia A.,Marzilli, Luigi G.. "Synthesis and Characterization of Pt(II) Complexes with Pyridyl Ligands: Elongated Octahedral Ion Pairs and Other Factors Influencing 1H NMR Spectra". supporting information. p. 9781 - 9793. Retrieved 2017/08/26.
• 7、 -. "Compound with antitumor activity, and preparation method and application thereof". Paragraph 0094; 0095; 0096; 0100. . Retrieved 2017/12/28.