3-Bromocyclobutanone

Base Information

• Chemical Name: 3-Bromocyclobutanone
• CAS No.: 23761-24-2
• Molecular Formula: C4H5BrO
• Molecular Weight: 148.987
• Hs Code.: 2914700090
• Mol file: 23761-24-2.mol

Synonyms:3-bromocyclobutan-1-one

Chemical Property of 3-Bromocyclobutanone

Chemical Property:

• Boiling Point: 29 °C(Press: 1.8 Torr)
• PSA: 17.07000
• Density: 1.820±0.06 g/cm3(Predicted)
• LogP: 1.11280
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromocyclobutanone 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromocyclobutanone

There total 2 articles about 3-Bromocyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-oxocyclobutanecarboxylic acid (23761-23-1) → 3-bromocyclobutan-1-one (23761-24-2)

Guidance literature:

With bromine; magnesium sulfate; silver(l) oxide; In dichloromethane; for 3h; Reflux;

Reference yield:

→ 3-bromocyclobutan-1-one (23761-24-2)

Guidance literature:

Saeure 3, HgO/Br2;

DOI:10.1021/ja00739a020

Reference yield: 96.0%

3-bromocyclobutan-1-one (23761-24-2) + benzyl alcohol (100-51-6,185532-71-2) → 3-benzyloxy cyclobutanone (30830-27-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 45 ℃; for 8h; Inert atmosphere;

upstream raw materials:

3-oxocyclobutanecarboxylic acid

Downstream raw materials:

2-cyclobuten-1-one

2-bromo-5,8-dioxaspiro[3,4]octane

3-benzyloxy cyclobutanone

cyclobutanone

Refernces

• 1、 Xue, Yibin,Dong, Guangbin. "Total Synthesis of Penicibilaenes via C-C Activation-Enabled Skeleton Deconstruction and Desaturation Relay-Mediated C-H Functionalization". . p. 8272 - 8277. Retrieved 2021.
• 2、 -. "Preparation method of 3-(benzyloxy)-1-cyclobutanone". Paragraph 0049-0051. . Retrieved 2020/07/12.
• 3、 -. "Fused Bicyclic Kinase Inhibitors". Page/Page column 59. . Retrieved 2011/11/30.