Ethyl 5-chloro-7-azaindol...

Base Information

• Chemical Name: Ethyl 5-chloro-7-azaindol...
• CAS No.: 1083181-28-5
• Molecular Formula: C10H9ClN2O2
• Molecular Weight: 224.64
• Hs Code.: 2933990090
• Mol file: 1083181-28-5.mol

Synonyms:ETHYL 5-CHLORO-1H-PYRAZOLO [2,3-B] PYRIDINE-2-CARBOXYLATE;

Chemical Property of Ethyl 5-chloro-7-azaindol...

Chemical Property:

• PSA: 54.98000
• LogP: 2.39300
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl5-Chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 5-chloro-7-azaindol...

There total 2 articles about Ethyl 5-chloro-7-azaindol... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H13ClN2O4S (1132610-97-9) → C10H9ClN2O2 (1083181-28-5)

Guidance literature:

With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; for 12h; Heating / reflux;

Reference yield:

5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (800401-84-7) + ethanol (64-17-5) → C10H9ClN2O2 (1083181-28-5)

Guidance literature:

With thionyl chloride; for 4h; Reflux; Inert atmosphere;

DOI:10.1021/ja305574k

Reference yield:

C10H9ClN2O2 (1083181-28-5) → C24H22ClIN2O5S

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: acetonitrile / 0.08 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ja305574k

upstream raw materials:

C₁₆H₁₃ClN₂O₄S

5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

ethanol

Downstream raw materials:

C₁₀H₈ClIN₂O₂

ethyl 5-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Refernces

• 1、 -. "2,3-SUBSTITUTED AZAINDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS". Page/Page column 90. . Retrieved 2009/04/25.