1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-chloro-

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-chloro-
• CAS No.: 800401-84-7
• Molecular Formula: C8H5ClN2O2
• Molecular Weight: 196.59
• Hs Code.: 2933990090
• Mol file: 800401-84-7.mol

Synonyms:5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-chloro-

Chemical Property:

• Refractive Index: 1.744
• PKA: 3.84±0.30(Predicted)
• PSA: 65.98000
• Density: 1.644 g/cm³
• LogP: 1.91450
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-1h-pyrrolo[2,3-b]pyridine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloro-1h-pyrrolo[2,3-b]pyridine-2-carboxylic acid

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-chloro-

There total 2 articles about 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-oxo-propionic acid (127-17-3) + 5-chloro-3-iodo-2-aminopyridine (211308-81-5) → 5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (800401-84-7)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; In N,N-dimethyl-formamide; at 110 ℃; for 16h;

Reference yield:

5-chloro-2-pyridylamine (1072-98-6) → 5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (800401-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; silver sulfate / ethanol / 72 h / 20 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / palladium diacetate / DMF (N,N-dimethyl-formamide) / 16 h / 110 °C

With 1,4-diaza-bicyclo[2.2.2]octane; iodine; silver sulfate; palladium diacetate; In DMF (N,N-dimethyl-formamide); ethanol; 2: Heck Reaction;

Reference yield:

5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (800401-84-7) + (S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride (123665-42-9,1175090-79-5) → 5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (1-dimethylcarbamoyl-2-(S)-phenylethyl)amide

Guidance literature:

With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In ethanol; at 20 ℃; for 24h;

upstream raw materials:

2-oxo-propionic acid

5-chloro-3-iodo-2-aminopyridine

5-chloro-2-pyridylamine

Downstream raw materials:

ethyl 5-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

C₁₀H₉ClN₂O₂

2-(S)-[(5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carbonyl)amino]-3-(4-fluorophenyl)propionic acid

Refernces

• 1、 -. "PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDES". Page/Page column 21. . Retrieved 2008/06/13.