4-Methoxy-2-methylbenzyl alcohol

Base Information

• Chemical Name: 4-Methoxy-2-methylbenzyl alcohol
• CAS No.: 52289-55-1
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• Hs Code.: 2909499000
• European Community (EC) Number: 675-454-1
• DSSTox Substance ID: DTXSID00374854
• Nikkaji Number: J1.270.792D
• Wikidata: Q82163425
• Mol file: 52289-55-1.mol

Synonyms:4-Methoxy-2-methylbenzyl alcohol;52289-55-1;(4-methoxy-2-methylphenyl)methanol;(2-methyl-4-methoxyphenyl)methanol;SCHEMBL3127408;2-Methyl-4-methoxyphenylmethanol;DTXSID00374854;HIGOQWJOANGLIL-UHFFFAOYSA-N;CCA28955;AKOS009159534;FS-1699;CS-0196205;FT-0704250;E89723

Chemical Property of 4-Methoxy-2-methylbenzyl alcohol

Chemical Property:

• Boiling Point: 95°C/0.1mm
• PSA: 29.46000
• LogP: 1.49590
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 114

Purity/Quality:

99%min ^*data from raw suppliers

4-Methoxy-2-methylbenzylalcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)OC)CO

Technology Process of 4-Methoxy-2-methylbenzyl alcohol

There total 15 articles about 4-Methoxy-2-methylbenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxysalicylaldehyde (52289-54-0) → (4-methoxy-2-methylphenyl)methanol (52289-55-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 0.0833333h;

DOI:10.1016/j.bmcl.2017.06.015

Reference yield: 100.0%

methyl 4-methoxy-2-methylbenzoate (35598-05-1) → (4-methoxy-2-methylphenyl)methanol (52289-55-1)

Guidance literature:

With lithium aluminium tetrahydride; Celite; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1016/S0040-4020(01)89106-7

Reference yield: 91.0%

4-methoxy-2-methylbenzoic acid (6245-57-4) → (4-methoxy-2-methylphenyl)methanol (52289-55-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16.5h; Inert atmosphere;

upstream raw materials:

4-methoxy-2-methylbenzyl chloride

acetic acid

methyl 4-methoxy-2-methylbenzoate

4-methoxy-2-methylbenzoic acid

Downstream raw materials:

4-methoxy-2-methylbenzyl chloride

acetic acid 4-methoxy-2-methyl-benzyl ester

2,4-dibromo-5-methylanisole

4-bromo-3-methylanisole

Refernces

• 1、 Gong, Mengdie,Li, Honglin,Li, Lu,Li, Shiliang,Sun, Hongxia,Tu, Mingyan,Zhao, Zhenjiang,Zhu, Lili. "Design, synthesis, and structure–activity relationship study of potent mapk11 inhibitors". supporting information. . Retrieved 2022/01/04.
• 2、 -. "COMPOUNDS FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE". Page/Page column 47; 49; 55; 63-64; 74; 76; 79; 81; 82; 90; 91. . Retrieved 2019/11/19.