4-Methoxy-2-methylbenzoic acid

Base Information

• Chemical Name: 4-Methoxy-2-methylbenzoic acid
• CAS No.: 6245-57-4
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Hs Code.: 29189900
• Mol file: 6245-57-4.mol

Synonyms:RARECHEM AL BE 0867;

Chemical Property of 4-Methoxy-2-methylbenzoic acid

Chemical Property:

• Appearance/Colour: white to slightly cream crystalline powder
• Vapor Pressure: 0.000741mmHg at 25°C
• Melting Point: 177-181 °C(lit. )
• Refractive Index: 1.54
• Boiling Point: 294.3 °C at 760 mmHg
• PKA: 4.32±0.25(Predicted)
• Flash Point: 118.6 °C
• PSA: 46.53000
• Density: 1.168 g/cm³
• LogP: 1.70180
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxy-2-methylbenzoic acid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Methoxy-2-methylbenzoic acid may be used in the synthesis of 4-methoxy-2-methylbenzoates of Y(III) and lanthanides (III) (La to Lu, excluding Pm). It may also be used to synthesize 4-methoxy-2-methylbenzoic acid hydrazide and 5-bromo-4-methoxy-2-methylbenzoic acid.

Technology Process of 4-Methoxy-2-methylbenzoic acid

There total 60 articles about 4-Methoxy-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

carbon dioxide (124-38-9,18923-20-1) + 4-bromo-3-methylanisole (27060-75-9) → 4-methoxy-2-methylbenzoic acid (6245-57-4)

Guidance literature:

carbon dioxide; 4-bromo-3-methylanisole; With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1016/j.bmc.2010.04.041

Reference yield: 98.0%

carbon dioxide (124-38-9,18923-20-1) + 2-methyl-4-methoxyphenylmagnesium bromide (148706-30-3) → 4-methoxy-2-methylbenzoic acid (6245-57-4)

Guidance literature:

carbon dioxide; 2-methyl-4-methoxyphenylmagnesium bromide; In tetrahydrofuran; at 20 ℃; under 3000.3 Torr; gas-liquid flow reactor assembly;

With polymer-supported sulfonic acid; In tetrahydrofuran;

DOI:10.1002/anie.201006618

Reference yield: 97.0%

1-ethynyl-4-methoxy-2-methylbenzene (74331-69-4) → 4-methoxy-2-methylbenzoic acid (6245-57-4)

Guidance literature:

With methyl 3,5-bis((1H-1,2,4-triazol-1-yl)methyl)benzoate; oxygen; sodium acetate; nickel dibromide; at 120 ℃; for 48h; under 760.051 Torr;

DOI:10.1039/c5cc00750j

upstream raw materials:

4-methoxysalicylaldehyde

(4-methoxy-2-methylphenyl)methanol

1-iodo-4-methoxy-2-methylbenzene

methyl 4-methoxy-2-methylbenzoate

Downstream raw materials:

methyl 2-(bromomethyl)-4-(methyloxy)benzoate

C₂₁H₂₀N₂O₅S

R-2-(2,4-difluorophenylamino)-8-(2,3-dihydroxypropoxy)-10,11-dihydrodibenzo-[a,d]cyclohepten-5-one

S-2-(2,4-difluorophenylamino)-8-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-10,11-dihydro-dibenzo[a,d]cyclohepten-5-one

Refernces

• 1、 -. "6-chloro-5-hydroxyisoindole-1-one and synthesis method thereof". Paragraph 0024-0026; 0037-0039; 0050-0052. . Retrieved 2020/11/23.
• 2、 -. "Chemical synthesis method of 6-bromo-5-hydroxyl iso-indolin-1-ketone". Paragraph 0007; 0023-0025; 0036-0038; 0049-0051. . Retrieved 2019/01/14.