4-(chloroMethyl)-5-Methyl-1H-iMidazole

Base Information

• Chemical Name: 4-(chloroMethyl)-5-Methyl-1H-iMidazole
• CAS No.: 69395-89-7
• Molecular Formula: C5H7ClN2
• Molecular Weight: 130.577
• Hs Code.: 2933290090
• Mol file: 69395-89-7.mol

Synonyms:4-(chloroMethyl)-5-Methyl-1H-iMidazole;4-(Chloromethyl)-5-methylimidazole;4-Methyl-5-chloromethylimidazole;5-(chloromethyl)-4-methyl-1H-Imidazole

Chemical Property of 4-(chloroMethyl)-5-Methyl-1H-iMidazole

Chemical Property:

• PSA: 28.68000
• Density: 1.244
• LogP: 1.45690

Purity/Quality:

99% ^*data from raw suppliers

5-(Chloromethyl)-4-methyl-1H-imidazole hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(chloroMethyl)-5-Methyl-1H-iMidazole

There total 4 articles about 4-(chloroMethyl)-5-Methyl-1H-iMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4(5)-methyl-5(4)-hydroxymethylimidazole (29636-87-1) → 5-methyl-4-chloromethyl imidazole (69395-89-7)

Guidance literature:

With thionyl chloride;

DOI:10.1021/jm020819i DOI:10.1021/jm070447j

Reference yield:

4-hydroxymethyl-5-methylimidazole hydrochloride (38585-62-5) → 5-methyl-4-chloromethyl imidazole (69395-89-7)

Guidance literature:

With thionyl chloride; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.ejmech.2018.05.051

Reference yield:

→ 5-methyl-4-chloromethyl imidazole (69395-89-7)

Guidance literature:

Methyl-Imidazol *HCl, POCl3;

upstream raw materials:

4⁽⁵⁾-methyl-5⁽⁴⁾-hydroxymethylimidazole

4-hydroxymethyl-5-methylimidazole hydrochloride

Downstream raw materials:

2-benzoyl-4,5-dimethylimidazole

4,5-dimethylimidazole

4⁽⁵⁾-(cyanomethyl)-5⁽⁴⁾-methylimidazole

Refernces

• 1、 Madsen, Christian,Jensen, Anders A.,Liljefors, Tommy,Kristiansen, Uffe,Nielsen, Birgitte,Hansen, Camilla P.,Larsen, Mogens,Ebert, Bjarke,Bang-Andersen, Benny,Krogsgaard-Larsen, Povl,Fr?lund, Bente. "5-Substituted imidazole-4-acetic acid analogues: Synthesis, modeling, and pharmacological characterization of a series of novel γ-aminobutyric acidC receptor agonists". . p. 4147 - 4161. Retrieved 2008/02/13.
• 2、 -. "Imidazole-containing inhibitors of farnesyl protein transferase". . . Retrieved 2008/06/13.