Technology Process of 2-(2-methylpropyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)Benzonitrile
There total 9 articles about 2-(2-methylpropyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)Benzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate;
In
1,4-dioxane; water;
at 100 ℃;
Inert atmosphere;
DOI:10.1021/acsmedchemlett.7b00476
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / toluene; water / 16 h / 100 °C / Inert atmosphere
2.1: zinc; water; ammonium formate / methanol / 4 h / 80 °C
3.1: sodium nitrite; hydrogen bromide / acetonitrile / 0.5 h / 0 °C
3.2: 16 h / 20 °C
4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere
With
water; hydrogen bromide; ammonium formate; potassium acetate; caesium carbonate; zinc; sodium nitrite;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; methanol; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: zinc; water; ammonium formate / methanol / 4 h / 80 °C
2.1: sodium nitrite; hydrogen bromide / acetonitrile / 0.5 h / 0 °C
2.2: 16 h / 20 °C
3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere
With
water; hydrogen bromide; ammonium formate; potassium acetate; zinc; sodium nitrite;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; methanol; acetonitrile;