Zolpidem

Base Information

• Chemical Name: Zolpidem
• CAS No.: 82626-48-0
• Molecular Formula: C19H21N3O
• Molecular Weight: 307.395
• Hs Code.: 2933996500
• European Community (EC) Number: 617-367-3
• UNII: 7K383OQI23
• DSSTox Substance ID: DTXSID7045946
• Nikkaji Number: J33.161I
• Wikipedia: Zolpidem
• Wikidata: Q218842
• NCI Thesaurus Code: C62000
• RXCUI: 39993
• Pharos Ligand ID: TF7FWLNCSVL1
• Metabolomics Workbench ID: 38709
• ChEMBL ID: CHEMBL911
• Mol file: 82626-48-0.mol

Synonyms:Ambien;Amsic;Bikalm;Dalparan;Imidazo(1,2-a)pyridine-3-acetamide, N,N,6-trimethyl-2-(4-methylphenyl)-;N,N,6-trimethyl-2-(4-methylphenyl)imidazo(1,2a)pyridine-3-acetamide hemitartrate;SL 80.0750;SL 800750 23 N;SL-800750-23-N;Stilnoct;Stilnox;zodormdura;Zoldem;Zolirin;Zolpi Lich;Zolpi-Lich;zolpidem;Zolpidem 1A Pharma;Zolpidem AbZ;Zolpidem Hemitartrate;zolpidem tartrate;Zolpimist;Zolpinox

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Zolpidem

Chemical Property:

• Appearance/Colour: White to off-white crystalline powder
• Melting Point: 189-191 °C
• Refractive Index: 1.601
• PKA: 6.2(at 25℃)
• Flash Point: 9℃
• PSA: 37.61000
• Density: 1.12 g/cm³
• LogP: 3.24880
• Storage Temp.: Store at RT
• Solubility.: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
• Water Solubility.: <10mg/L(room temperature)
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 307.168462302
• Heavy Atom Count: 23
• Complexity: 417

Purity/Quality:

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Drug Classes: Sedatives and Hypnotics
• Canonical SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C
• Recent ClinicalTrials: The Effects of Castration on the Pharmacokinetics of Zolpidem After Single Dose Administration In Men With Prostate Cancer Undergoing Androgen Deprivation Therapy Compared to Normal Healthy Females
• Recent EU Clinical Trials: Self-help program for hypnotics withdrawal in insomniac patients: A randomized controlled clinical trial.
• Recent NIPH Clinical Trials: A Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42847922 in Participants with Insomnia Disorder
• Description: Zolpidem hemitamwe is a non-benzodiazepine hypnotic with specific agonist activity at type 1 benzodiazepine receptors, and is indicated for use in insomnia and other sleep disorders. Structurally zolpidem belongs to a chemically distinct class, thus lacking the side-effects and abuse potential of classical benzodiazepines. It is currently being studied as a pre-operative sedative. Zolpidem (Item No. 15792) is an analytical reference material that is functionally categorized as a sedative. It is a non-benzodiazepine drug that is used in the treatment of insomnia, and it has been recreationally abused. This product is intended for research and forensic applications. Zolpidem (Item No. 20648) is a certified reference material that is functionally categorized as a sedative. It is a non-benzodiazepine drug that is used in the treatment of insomnia, and it has been recreationally abused. This product is intended for research and forensic applications.
• Uses: A selective benzodiazepine receptor agonist not related chemically to benzodiazepines A selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic. Controlled substance (depresssant).

Technology Process of Zolpidem

There total 60 articles about Zolpidem which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

N,N,6-trimethyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine-3-acetamide hydrochloride → N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide (82626-48-0)

Guidance literature:

With sodium carbonate; at 0 - 10 ℃; for 0.5h; pH=9; Large scale;

Reference yield: 97.0%

α-hydroxy-zolpidem-O-propionate (722553-25-5) → N,N,6-trimethyl-2-(4-methylphenyl)-imidazo[1,2-α]pyridine-3-α-hydroxyacetamide (118026-14-5) + N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide (82626-48-0)

Guidance literature:

α-hydroxy-zolpidem-O-propionate; With sulfuric acid; sodium bromide; In water; acetic acid;

With hydrogen; 5% Pd-BaSO4; In water; acetic acid; for 12.5h; under 1551.49 - 2068.65 Torr;

Reference yield: 97.0%

α-hydroxy-zolpidem-O-propionate (722553-25-5) → N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide (82626-48-0)

Guidance literature:

With sulfuric acid; hydrogen; acetic acid; sodium bromide; 5% Pd-BaSO4; In water; for 12.5h; under 1551.49 - 2068.65 Torr; Product distribution / selectivity;

upstream raw materials:

dimethyl amine

6-methyl-2-(4-methylphenyl)-imidazo<1,2-a>pyridine-3-acetic acid

6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine

2-(4-methylphenyl)-6-methylimidazo[1,2-α]pyridine-3-acetamide

Downstream raw materials:

N,N,6-trimethyl-2-(4-methylphenyl)-imidazo[1,2-α]pyridine-3-α-hydroxyacetamide

6-methyl-2-(4-methylphenyl)-imidazo<1,2-a>pyridine-3-acetic acid

(R,S)-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine

Refernces

• 1、 Zhang, Bingbing,Shan, Guangsheng,Ma, Qiaoning,Xu, Qianqian,Lei, Xinsheng. "An improved and scalable synthesis of zolpidem via a CuI/BINOL-mediated tandem reaction of imine and alkyne". . p. 445 - 448. Retrieved 2017.
• 2、 Wu, Qingguo,Yang, Haifeng,Zhang, Jian,Zhang, Jie,Zhang, Yufeng. "Synthesis of C3-Cyanomethylated Imidazo[1,2- a ]pyridines via Ultrasound-Promoted Three-Component Reaction under Catalyst- and Oxidant-Free Conditions". . p. 264 - 268. Retrieved 2022/02/05.
• 3、 -. "Preparation method of zolpidem". Paragraph 0021; 0077-0086. . Retrieved 2021/08/19.