1-Boc-3-fluoropyrrolidine

Base Information

• Chemical Name: 1-Boc-3-fluoropyrrolidine
• CAS No.: 518063-52-0
• Molecular Formula: C9H16FNO2
• Molecular Weight: 189.23
• Mol file: 518063-52-0.mol

Synonyms:tert-butyl 3-fluoropyrrolidine-1-carboxylate;3-Fluoro-1-pyrrolidinecarboxylic acid tert-butyl ester;N-tert-Butoxycarbonyl-3-fluoropyrrolidine

Chemical Property of 1-Boc-3-fluoropyrrolidine

Chemical Property:

• Boiling Point: 230℃
• Flash Point: 93℃
• PSA: 29.54000
• Density: 1.08
• LogP: 1.90320
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl3-fluoropyrrolidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-3-fluoropyrrolidine

There total 6 articles about 1-Boc-3-fluoropyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.8%

1-N-tert-butoxycarbonyl-3-trifluoromethanesulfonyloxypyrrolidine → tert-butyl 3-fluoropyrrolidine-1-carboxylate (518063-52-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; Inert atmosphere; Reflux;

Reference yield: 79.0%

N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine (103057-44-9,83220-73-9) → tert-butyl 3-fluoropyrrolidine-1-carboxylate (518063-52-0)

Guidance literature:

N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine; With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -10 - -5 ℃;

In dichloromethane; at 20 ℃; Further stages.;

DOI:10.1021/jo8015659

Reference yield: 75.0%

3-bromopyrrolidine-1-carboxylic acid tert-butyl ester (939793-16-5,569660-97-5) → tert-butyl 3-fluoropyrrolidine-1-carboxylate (518063-52-0)

Guidance literature:

With potassium phosphate; benzophenone; 1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)-2-trisilanol; N-fluorobis(benzenesulfon)imide; In water; acetonitrile; at 20 ℃; for 4h; Irradiation; Inert atmosphere;

DOI:10.1021/jacs.9b11434

upstream raw materials:

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine

3-bromopyrrolidine-1-carboxylic acid tert-butyl ester

tert-butyl pyrrolidine-1-carboxylate

Downstream raw materials:

3-fluoropyrrolidine hydrochloride

3-fluoro-pyrrolidine dihydrochloride

Refernces

• 1、 -. "Halogen-substituted latrotinib compound". . . Retrieved 2021/02/10.
• 2、 -. "KRAS G12C INHIBITORS". Paragraph 0247. . Retrieved 2020/03/23.