CORYSAMINE CHLORIDE(RG)

Base Information

• Chemical Name: CORYSAMINE CHLORIDE(RG)
• CAS No.: 11028-77-6
• Molecular Formula: C20H16ClNO4
• Molecular Weight: 369.8
• Mol file: 11028-77-6.mol

Synonyms:CORYSAMINE CHLORIDE(RG)

Chemical Property of CORYSAMINE CHLORIDE(RG)

Chemical Property:

• Melting Point: >290 °C (decomp)
• PSA: 40.80000
• LogP: 0.12020

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CORYSAMINE CHLORIDE(RG)

There total 6 articles about CORYSAMINE CHLORIDE(RG) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

13-methylene-2,3:9,10-bis(methylenedioxy)-8,14-cycloberbine (100986-36-5) → corysamine chloride (11028-77-6)

Guidance literature:

In ethanol; at -20 ℃; for 1h; Irradiation;

DOI:10.1248/cpb.37.3264

Reference yield: 80.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Dihydrocoptisine (53777-78-9) → corysamine chloride (11028-77-6)

Guidance literature:

formaldehyd; Dihydrocoptisine; With acetic acid; In ethanol; Reflux;

With hydrogenchloride; In methanol; ethanol; at 20 ℃;

DOI:10.1021/acs.jmedchem.5b00964

Reference yield:

C20H16NO4(1+)*C2H3O2(1-) → corysamine chloride (11028-77-6)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2014.09.006

upstream raw materials:

13-methylene-2,3:9,10-bis(methylenedioxy)-8,14-cycloberbine

C₁₉H₁₃NO₅

Dihydrocoptisine

coptisine chloride

Refernces

• 1、 Zhang, Zhi-Hui,Deng, An-Jun,Wu, Lian-Qiu,Fang, Lian-Hua,Yu, Jin-Qian,Li, Zhi-Hong,Yuan, Tian-Yi,Wang, Wen-Jie,Du, Guan-Hua,Qin, Hai-Lin. "Syntheses and structure-activity relationships in cytotoxicities of 13-substituted quaternary coptisine derivatives". . p. 542 - 549. Retrieved 2014.
• 2、 Hanaoka, Miyoji,Yoshida, Shuji,Mukai, Chisato. "A Novel and Efficient Synthesis of 13-Methylprotoberberine Alkaloids". . p. 1257 - 1258. Retrieved 2007/10/02.