1H-1-Ethyl Candesartan Cilexetil

Base Information

• Chemical Name: 1H-1-Ethyl Candesartan Cilexetil
• CAS No.: 914613-35-7
• Molecular Formula: C35H38N6O6
• Molecular Weight: 638.71282
• Mol file: 914613-35-7.mol

Synonyms:1H-1-Ethyl Candesartan Cilexetil;2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester;2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-;Candesartan Cilexetil EP IMpurity E

Chemical Property of 1H-1-Ethyl Candesartan Cilexetil

Chemical Property:

• Melting Point: 90-93°C
• Boiling Point: 842.0±75.0 °C(Predicted)
• PKA: 3.95±0.10(Predicted)
• PSA: 132.48000
• Density: 1.32
• LogP: 6.81240
• Storage Temp.: Refrigerator
• Solubility.: ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide

Purity/Quality:

> 95% ^*data from raw suppliers

1H-1-EthylCandesartanCilexetil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Candesartan Cilexetil Impurity E (PHARMEUROPA).

Technology Process of 1H-1-Ethyl Candesartan Cilexetil

There total 2 articles about 1H-1-Ethyl Candesartan Cilexetil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl iodide (75-03-6) + candesartan cilexetil (145040-37-5) → (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (914613-35-7) + (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (914613-36-8)

Guidance literature:

candesartan cilexetil; With potassium carbonate; In acetone; at 20 ℃; for 1h; Inert atmosphere;

ethyl iodide; In acetone; at 20 ℃; for 24h;

DOI:10.1135/cccc2008072

Reference yield:

candesartan cilexetil (145040-37-5) → (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-oxo-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylate (869631-11-8) + (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (914613-35-7) + (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (914613-36-8)

Guidance literature:

at 55 ℃; for 336h; Product distribution / selectivity;

Reference yield: 68.8%

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (914613-35-7) → 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 3-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2-oxo-2,3-dihydro-1H-benzimidazole-4-carboxylate (1185255-99-5)

Guidance literature:

With hydrogenchloride; water; In acetone; at 75 ℃; for 6h; Heating;

DOI:10.1135/cccc2008072

upstream raw materials:

candesartan cilexetil

ethyl iodide

Downstream raw materials:

1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 3-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2-oxo-2,3-dihydro-1H-benzimidazole-4-carboxylate

Refernces

• 1、 -. "STABLE MICRONIZED CANDESARTAN CILEXETIL AND METHODS FOR PREPARING THEREOF". Page/Page column 12; 13. . Retrieved 2008/06/13.