(4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine

Base Information

• Chemical Name: (4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine
• CAS No.: 932710-63-9
• Molecular Formula: C16H28NP
• Molecular Weight: 265.379
• Hs Code.: 2921420090
• European Community (EC) Number: 802-197-6
• DSSTox Substance ID: DTXSID10471005
• Nikkaji Number: J2.315.181B
• Mol file: 932710-63-9.mol

Synonyms:932710-63-9;4-(Di-tert-butylphosphino)-N,N-dimethylaniline;(4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine;Bis(di-tert-butyl)-4-dimethylaminophenylphosphine;4-(di-tert-butylphosphanyl)-N,N-dimethylaniline;4-ditert-butylphosphanyl-N,N-dimethylaniline;(4-Dimethylaminophenyl)di-tert-butylphosphine;A-taPhos;C16H28NP;APhos, 95%;4-ditert-butylphosphanyl-N,N-dimethyl-aniline;SCHEMBL616862;DTXSID10471005;IQTHEAQKKVAXGV-UHFFFAOYSA-N;AMY11705;AKOS016012292;CS-W010126;p-dimethylaminophenyl-di-t-butylphosphine;AS-66913;4-(di-t-butylphosphino)-N,N-dimethylaniline;D4531;FT-0700602;EN300-193299;F10229;[4-(Dimethylamino)phenyl]Bis(tertbutyl)phosphine;A922750;(4-(N,N-dimethylamino)phenyl)-di-t-butylphosphine;Y-200027;[4-(N,N-DIMETHYLAMINO)PHENYL]DI-T-BUTYLPHOSPHINE

Chemical Property of (4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine

Chemical Property:

• Melting Point: 57-61°C
• Boiling Point: 349.1±25.0 °C(Predicted)
• PKA: 4.73±0.24(Predicted)
• PSA: 16.83000
• LogP: 4.45680
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: soluble in Acetone
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 265.195936895
• Heavy Atom Count: 18
• Complexity: 237

Purity/Quality:

98% ^*data from raw suppliers

Amphos ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)P(C1=CC=C(C=C1)N(C)C)C(C)(C)C
• Uses: Amphos can be used as an electrophotographic photoreceptor, process cartridge, and image forming electrode. Ligand used to prepare a palladium dichloride catalyst (678740) on treatment with PdCl2(COD). The catalyst effectively cross-couples aryl boronic acids with heteroaryl chlorides.

Technology Process of (4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine

There total 9 articles about (4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

di-tert-butylphosphonium chloride + N,N-dimethyl-aniline (121-69-7,77733-26-7) → (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine (932710-63-9)

Guidance literature:

With dmap; copper (I) acetate; In toluene; at 120 ℃; for 8h; Temperature; Inert atmosphere;

Reference yield: 85.0%

di(tert-butyl)chlorophosphine (13716-10-4) + 4-N,N-dimethylaminophenyl magnesium chloride (108949-55-9) → (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine (932710-63-9)

Guidance literature:

di(tert-butyl)chlorophosphine; 4-N,N-dimethylaminophenyl magnesium chloride; at -30 ℃; for 0.166667h; Inert atmosphere;

With ammonium chloride; In water; at -30 ℃; for 0.5h;

Reference yield: 85.0%

di(tert-butyl)chlorophosphine (13716-10-4) + 4-dimethylaminophenylmagnesium bromide (7353-91-5) → (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine (932710-63-9)

Guidance literature:

di(tert-butyl)chlorophosphine; 4-dimethylaminophenylmagnesium bromide; at -60 ℃; for 0.133333h; Inert atmosphere;

With ammonium chloride; In water; at -60 ℃; for 0.5h;

upstream raw materials:

di-tert-butylphosphine

4-bromo-N,N-dimethylaniline

N,N-dimethyl-aniline

di(tert-butyl)chlorophosphine

Downstream raw materials:

[Pd(Amphos)(cinnamyl)Cl]

[Pd(4-(di-tert-butylphosphino)-N,N-dimethylaniline)(trifluoroacetate)(κ2-N,C-C6H4CH2NMe2)]

9-{5-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-o-[4-(1,3-oxazol-2-yl)benzyl]-β-D-ribofuranosyl}-6-[2-(trimethylsilyl)ethoxy]-9H-purine

bis[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium⁽⁰⁾

Refernces

• 1、 -. "Di-tert-butyl - 4 - dimethyl amino phosphonate and double (di-tert-butyl - 4 - dimethyl amino phosphonate) preparation method of catalysts". Paragraph 0061-0063. . Retrieved 2017/08/25.
• 2、 -. "NOVEL CATALYSTS". Page/Page column 71. . Retrieved 2012/06/01.