2-(Diisopropylsilyl)pyridine

Base Information

• Chemical Name: 2-(Diisopropylsilyl)pyridine
• CAS No.: 1232692-92-0
• Molecular Formula: C11H19NSi
• Molecular Weight: 193.364
• Mol file: 1232692-92-0.mol

Synonyms:2-(Diisopropylsilyl)pyridine;PyDipSiH;Pyridyldiisopropylsilane

Chemical Property of 2-(Diisopropylsilyl)pyridine

Chemical Property:

• Refractive Index: 1.4930-1.4960
• Flash Point: 84°C(lit.)
• PSA: 12.89000
• Density: 0.917 g/mL at 25 °C
• LogP: 2.33570
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Diisopropylsilyl)pyridine >95.0%(GC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Diisopropylsilyl)pyridine

There total 1 articles about 2-(Diisopropylsilyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-bromo-pyridine (109-04-6) + chlorodiisopropylsilane (2227-29-4) → 2-(diisopropylsilyl)pyridine (1232692-92-0)

Guidance literature:

2-bromo-pyridine; With n-butyllithium; In hexanes; diethyl ether; at -78 ℃; for 0.666667h; Inert atmosphere;

chlorodiisopropylsilane; In hexanes; diethyl ether; dibutyl ether; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ja1033167

Reference yield: 99.0%

iodobenzene (591-50-4) + 2-(diisopropylsilyl)pyridine (1232692-92-0) → 2-(diisopropyl(phenyl)silyl)pyridine (1232692-88-4)

Guidance literature:

With potassium phosphate; di-μ-chlorobis(norbornadiene)dirhodium(I); In 1,4-dioxane; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1002/adsc.201000975

Reference yield: 99.0%

4-Iodoacetophenone (13329-40-3) + 2-(diisopropylsilyl)pyridine (1232692-92-0) → C19H25NOSi (1312936-24-5)

Guidance literature:

With potassium phosphate; di-μ-chlorobis(norbornadiene)dirhodium(I); In 1,4-dioxane; at 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.201000975

upstream raw materials:

2-bromo-pyridine

chlorodiisopropylsilane

Downstream raw materials:

2-(diisopropyl(4-methoxyphenyl)silyl)pyridine

2-(diisopropyl(3-(trifluoromethyl)phenyl)silyl)pyridine

2-(diisopropyl(3-methoxyphenyl)silyl)pyridine

2-((4-chlorophenyl)diisopropylsilyl)pyridine

Refernces

• 1、 Chernyak, Natalia,Dudnik, Alexander S.,Huang, Chunhui,Gevorgyan, Vladimir. "PyDipSi: A general and easily modifiable/traceless Si-tethered directing group for C-H acyloxylation of arenes". supporting information; experimental part. p. 8270 - 8272. Retrieved 2010/08/04.