2-(benzyloxy)-3-bromobenzamide

Base Information

• Chemical Name: 2-(benzyloxy)-3-bromobenzamide
• CAS No.: 862992-92-5
• Molecular Formula: C₁₄H₁₂BrNO₂
• Molecular Weight: 306.159
• Mol file: 862992-92-5.mol

Synonyms:2-(benzyloxy)-3-bromobenzamide

Chemical Property of 2-(benzyloxy)-3-bromobenzamide

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzyloxy)-3-bromobenzamide

There total 1 articles about 2-(benzyloxy)-3-bromobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3-bromo-2-hydroxybenzamide (28165-47-1) + benzyl bromide (100-39-0) → 2-benzyloxy-3-bromo-benzamide (862992-92-5)

Guidance literature:

With potassium carbonate; In acetone; for 12h;

Reference yield: 89.0%

2-benzyloxy-3-bromo-benzamide (862992-92-5) → 2-benzyloxy-3-bromo-benzonitrile (862992-93-6)

Guidance literature:

With thionyl chloride; for 12h; Heating / reflux;

Reference yield:

2-benzyloxy-3-bromo-benzamide (862992-92-5) + 3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester (900503-08-4) + trifluoroacetic acid (76-05-1) → 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-hydroxybenzamide trifluoroacetate (1123661-07-3) + 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide trifluoroacetate (1123661-03-9)

Guidance literature:

2-benzyloxy-3-bromo-benzamide; 3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester; With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; Heating / reflux;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

3-bromo-2-hydroxybenzamide

benzyl bromide

Downstream raw materials:

2-benzyloxy-3-bromo-benzonitrile

3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-hydroxybenzamide trifluoroacetate

3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide trifluoroacetate

8-benzyl-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-benzyloxybenzamide

Refernces