Technology Process of 5α-Androstan-5-ol
There total 6 articles about 5α-Androstan-5-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 76 percent / pyridine; various solvent(s) / 24 h / 0 °C
2: 90 percent / toluene / 460 °C
3: 1.0 g / hydrogen / chloro-tris(triphenylphosphine)rhodium / ethanol / 4 h / Ambient temperature
4: 1.) 1,2-ethanedithiol, boron trifluoride etherate; 2.) methanol / 2.) Raney-Ni / 1.) acetic acid, r.t., 2 d; 2.) 20 h
5: 1.) m-chloroperbenzoic acid; 2.) lithium aluminium hydride / 1.) CHCl3, r.t., 1 h; 2.) dioxane, reflux, 4 h
With
methanol; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; ethane-1,2-dithiol; 3-chloro-benzenecarboperoxoic acid;
Wilkinson's catalyst; nickel;
In
pyridine; ethanol; toluene;
DOI:10.1002/hlca.19830660121
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / toluene / 460 °C
2: 1.0 g / hydrogen / chloro-tris(triphenylphosphine)rhodium / ethanol / 4 h / Ambient temperature
3: 1.) 1,2-ethanedithiol, boron trifluoride etherate; 2.) methanol / 2.) Raney-Ni / 1.) acetic acid, r.t., 2 d; 2.) 20 h
4: 1.) m-chloroperbenzoic acid; 2.) lithium aluminium hydride / 1.) CHCl3, r.t., 1 h; 2.) dioxane, reflux, 4 h
With
methanol; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; ethane-1,2-dithiol; 3-chloro-benzenecarboperoxoic acid;
Wilkinson's catalyst; nickel;
In
ethanol; toluene;
DOI:10.1002/hlca.19830660121
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.0 g / hydrogen / chloro-tris(triphenylphosphine)rhodium / ethanol / 4 h / Ambient temperature
2: 1.) 1,2-ethanedithiol, boron trifluoride etherate; 2.) methanol / 2.) Raney-Ni / 1.) acetic acid, r.t., 2 d; 2.) 20 h
3: 1.) m-chloroperbenzoic acid; 2.) lithium aluminium hydride / 1.) CHCl3, r.t., 1 h; 2.) dioxane, reflux, 4 h
With
methanol; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; ethane-1,2-dithiol; 3-chloro-benzenecarboperoxoic acid;
Wilkinson's catalyst; nickel;
In
ethanol;
DOI:10.1002/hlca.19830660121