4-Hydroxy-1,5-naphthyridine

Base Information

• Chemical Name: 4-Hydroxy-1,5-naphthyridine
• CAS No.: 5423-54-1
• Molecular Formula: C₈H₆N₂O
• Molecular Weight: 146.148
• Hs Code.: 2933990090
• Mol file: 5423-54-1.mol

Synonyms:4-Hydroxy-1,5-naphthyridine;NSC 13205;

Chemical Property of 4-Hydroxy-1,5-naphthyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 340 °C (sublm)
• Refractive Index: 1.705
• Boiling Point: 332.682 °C at 760 mmHg
• PKA: 3.37±0.40(Predicted)
• Flash Point: 155.001 °C
• PSA: 46.01000
• Density: 1.348 g/cm³
• LogP: 1.33540
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,5-Naphthyridin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxy-1,5-naphthyridine

There total 11 articles about 4-Hydroxy-1,5-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,2-dimethyl-5-[(pyridin-3-ylamino)methylidene]-1,3-dioxane-4,6-dione (25063-68-7) → 4-hydroxy-1,5-naphthyridine (5423-54-1)

Guidance literature:

With dowtherm A; for 1h; Inert atmosphere; Reflux;

DOI:10.1021/acs.jmedchem.6b01379

Reference yield: 70.0%

3-carboxy-4-hydroxy-1,5-naphthyridine (4901-93-3,53512-10-0) → 4-hydroxy-1,5-naphthyridine (5423-54-1)

Guidance literature:

In mineral oil; at 330 ℃;

DOI:10.1002/jccs.201100671

Reference yield: 50.0%

C10H12N2O2 → 4-hydroxy-1,5-naphthyridine (5423-54-1)

Guidance literature:

In diphenylether; at 250 ℃; for 4h; Inert atmosphere;

upstream raw materials:

3-aminopyridin-4-ol

sulfuric acid

glycerol

1,5-naphthyridin-5-oxide 4-ol

Downstream raw materials:

4-bromo-1,5-naphthyridine

4-mercapto-1,5-naphthyridine

2-[2-methoxy-4-(1,5-naphthyridin-4-yloxy)phenyl]acetic acid

N¹,N¹-diethyl-N⁴-1,5-naphthyridin-4-ylpentane-1,4-diamine

Refernces

• 1、 -. "TOLL-LIKE RECEPTOR 8 (TLR8)-SPECIFIC ANTAGONISTS AND METHODS OF MAKING AND USES THEREOF". . . Retrieved 2019/05/22.
• 2、 -. "Fluorescent material as well as preparation method and application thereof". Paragraph 0063; 0065; 0067; 0068. . Retrieved 2019/07/08.