Technology Process of 4-Bromo-1,5-naphthyridine
There total 4 articles about 4-Bromo-1,5-naphthyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
phosphorus tribromide;
In
N,N-dimethyl-formamide;
for 1.16667h;
Inert atmosphere;
DOI:10.1016/j.bmcl.2012.08.109
- Guidance literature:
-
1,5-naphthyridine;
With
bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex;
In
tetrahydrofuran;
at -78 ℃;
for 0.0833333h;
Inert atmosphere;
With
1,2-dibromo-1,1,2,2-tetrachloroethane;
In
tetrahydrofuran;
at -78 - 25 ℃;
for 12h;
regioselective reaction;
Inert atmosphere;
DOI:10.1002/chem.201703638
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: iodine; sulfuric acid / 1,4-dioxane; water / 15 h / 0 - 150 °C / Inert atmosphere
2.1: bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
2.2: 12 h / -78 - 25 °C / Inert atmosphere
With
bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex; sulfuric acid; iodine;
In
tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1002/chem.201703638