Azure A

Base Information

• Chemical Name: Azure A
• CAS No.: 531-53-3
• Deprecated CAS: 1343-73-3,31772-57-3,789-65-1,8000-86-0,93211-80-4,959-03-5,1335204-67-5,9006-96-6,1335204-67-5,31772-57-3,789-65-1,8000-86-0,959-03-5
• Molecular Formula: C14H14ClN3S
• Molecular Weight: 291.804
• Hs Code.: 2934300000
• European Community (EC) Number: 257-438-2,208-510-7,263-491-2
• NSC Number: 326661
• UNII: M731V243EF
• DSSTox Substance ID: DTXSID2040157
• Wikipedia: Azure_A
• Wikidata: Q4833095
• Pharos Ligand ID: GL639CSNSP81
• ChEMBL ID: CHEMBL1091115,CHEMBL3330735
• Mol file: 531-53-3.mol

Synonyms:7-(dimethylamino)-3-imino-3H-phenothiazine hydrochloride;Azure A;Azure A bromide

Chemical Property of Azure A

Chemical Property:

• Appearance/Colour: green to dark brown powder
• Melting Point: 290 °C (dec.)(lit.)
• Boiling Point: 442.8oC at 760 mmHg
• Flash Point: 221.6oC
• PSA: 70.16000
• LogP: -0.39970
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: H2O: soluble1mg/mL
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 291.0596963
• Heavy Atom Count: 19
• Complexity: 483

Purity/Quality:

98%,99%, ^*data from raw suppliers

AzureA(TechnicalGrade) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Dyes -> Azine Dyes
• Canonical SMILES: C[N+](=C1C=CC2=NC3=C(C=C(C=C3)N)SC2=C1)C.[Cl-]
• Uses: Biological stain. For staining cell granules and tissues

Technology Process of Azure A

There total 9 articles about Azure A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methylene blue (152071-32-4,105504-42-5,121067-62-7,12262-49-6,167498-52-4,6476-03-5,97130-83-1) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + azure A (531-53-3)

Guidance literature:

With potassium bromate; ammonium vanadate; In sulfuric acid; at 25 ℃; for 0.166667h; Kinetics; Rate constant; Product distribution;

DOI:10.1021/j100349a015

Reference yield:

methylene blue (152071-32-4,105504-42-5,121067-62-7,12262-49-6,167498-52-4,6476-03-5,97130-83-1) → azure A (531-53-3)

Guidance literature:

With manganese(II,III) oxide; at 20 ℃; for 0.166667h; Reagent/catalyst;

DOI:10.1016/j.materresbull.2013.09.039

Reference yield:

→ azure A (531-53-3)

Guidance literature:

With potassium dichromate; water; at 65 ℃; Behandeln mit verd. Salzsaeure;

upstream raw materials:

3,7-bis(dimethylamine)phenothiazonium

methylene blue

dimethyl amine

dimethylthionine

Downstream raw materials:

formaldehyd

methylene blue

Refernces

• 1、 Shahab, Siyamak,Filippovich, Liudmila,Kumar, Rakesh,Darroudi, Mahdieh,Borzehandani, Mostafa Yousefzadeh,Gomar, Maryam,Hajikolaee, Fatemeh Haji. "Photochromic properties of the molecule Azure A chloride in polyvinyl alcohol matrix". . p. 109 - 115. Retrieved 2015.
• 2、 Muthakia, G. K.,Jonnalagadda, S. B.. "Uncatalyzed and V(V)-Catalyzed Reaction of Methylene Blue with Potassium Bromate in Aqueous Sulfuric Acid". . p. 4751 - 4756. Retrieved 2007/10/02.