1-BroMo-4-Methoxy-2-Methyl-5-nitrobenzene

Base Information

• Chemical Name: 1-BroMo-4-Methoxy-2-Methyl-5-nitrobenzene
• CAS No.: 89978-56-3
• Molecular Formula: C8H8BrNO3
• Molecular Weight: 246.06
• Hs Code.: 2909309090
• Mol file: 89978-56-3.mol

Synonyms:1-BroMo-4-Methoxy-2-Methyl-5-nitrobenzene

Chemical Property of 1-BroMo-4-Methoxy-2-Methyl-5-nitrobenzene

Chemical Property:

• PSA: 55.05000
• LogP: 3.19750
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-5-methyl-2-nitroanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BroMo-4-Methoxy-2-Methyl-5-nitrobenzene

There total 4 articles about 1-BroMo-4-Methoxy-2-Methyl-5-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-bromo-3-methylanisole (27060-75-9) → 1-bromo-4-methoxy-2-methyl-5-nitro-benzene (89978-56-3)

Guidance literature:

With nitric acid; acetic anhydride; Inert atmosphere;

DOI:10.1055/s-0036-1588752

Reference yield: 68.0%

4-bromo-3-methylanisole (27060-75-9) → 3-methyl-2,4,6-trinitrophenol (602-99-3) + 1-bromo-4-methoxy-2-methyl-5-nitro-benzene (89978-56-3) + 1-bromo-4-methoxy-2-methyl-3-nitro-benzene (85598-13-6)

Guidance literature:

With nitric acid; acetic anhydride; at 0 ℃; for 1h; regioselective reaction;

DOI:10.1002/jhet.512

Reference yield:

1-methoxy-3-methyl-benzene (100-84-5) → 1-bromo-4-methoxy-2-methyl-5-nitro-benzene (89978-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: nitric acid; acetic acid; trifluoroacetic acid / acetic acid / 2 h / -5 °C

With nitric acid; acetic acid; trifluoroacetic acid; In dichloromethane; acetic acid;

upstream raw materials:

4-bromo-5-methyl-2-nitrophenol

dimethyl sulfate

4-bromo-3-methylanisole

1-methoxy-3-methyl-benzene

Downstream raw materials:

1-[2-(4-methoxy-2-methyl-5-nitrophenylamino)phenyl]ethanone

4-bromo-5-methyl-2-nitrophenol

4-Methoxy-2-methyl-5-nitro-benzamide

Refernces

• 1、 -. "cGAS ANTAGONIST COMPOUNDS". Paragraph 0416. . Retrieved 2017/11/06.
• 2、 Radchenko, Oleg S.,Sigida, Elena N.,Balaneva, Nadezhda N.,Dmitrenok, Pavel S.,Novikov, Vyacheslav L.. "Abnormal reactions of 2-methoxy-4,9-dimethyl-1-nitroacridine with selenous acid and selenium(IV) oxide. Synthesis of 1H-selenopheno[2,3,4-k,l]acridine-1- one: A new seleno-containing ring system". experimental part. p. 209 - 214. Retrieved 2011/04/15.