4-bromo-5-methyl-2-nitrophenol

Base Information

• Chemical Name: 4-bromo-5-methyl-2-nitrophenol
• CAS No.: 182500-28-3
• Molecular Formula: C7H6BrNO3
• Molecular Weight: 232.034
• Hs Code.: 2908999090
• Mol file: 182500-28-3.mol

Synonyms:4-bromo-5-methyl-2-nitrophenol;2-Nitro-5-methyl-4-bromophenol

Chemical Property of 4-bromo-5-methyl-2-nitrophenol

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 126℃
• Boiling Point: 292.556°C at 760 mmHg
• PKA: 6.46±0.27(Predicted)
• Flash Point: 130.733°C
• PSA: 66.05000
• Density: 1.756g/cm³
• LogP: 2.89450

Purity/Quality:

95% ^*data from raw suppliers

4-Bromo-5-methyl-2-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-5-methyl-2-nitrophenol

There total 8 articles about 4-bromo-5-methyl-2-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-nitro-5-methylphenol (700-38-9) → 4-bromo-5-methyl-2-nitrophenol (182500-28-3)

Guidance literature:

With bromine; acetic acid; at 0 - 20 ℃; for 2.5h;

Reference yield: 98.0%

1-bromo-4-methoxy-2-methyl-5-nitro-benzene (89978-56-3) → 4-bromo-5-methyl-2-nitrophenol (182500-28-3)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃;

Reference yield:

4-bromo-3-methylphenol (14472-14-1) → 4-bromo-5-methyl-2-nitrophenol (182500-28-3)

Guidance literature:

With nitric acid; acetic acid;

upstream raw materials:

4-bromo-3-methylphenol

2-nitro-5-methylphenol

5-bromo-2-hydroxy-4-methylbenzoic acid

acetic acid

Downstream raw materials:

1-bromo-4-isopropoxy-2-methyl-5-nitro-benzene

5-bromo-2-methoxy-4-methyl-aniline

Refernces

• 1、 -. "SUBSTITUTED HETEROCYCLIC COMPOUNDS AS CRAC MODULATORS". Paragraph 0238. . Retrieved 2016/06/13.