Benzenamine, 5-bromo-2-methoxy-4-methyl- (9CI)

Base Information

• Chemical Name: Benzenamine, 5-bromo-2-methoxy-4-methyl- (9CI)
• CAS No.: 808133-98-4
• Molecular Formula: C8H10 Br N O
• Molecular Weight: 216.077
• Hs Code.: 2921420090
• Mol file: 808133-98-4.mol

Synonyms:5-Bromo-2-methoxy-4-methylaniline

Chemical Property of Benzenamine, 5-bromo-2-methoxy-4-methyl- (9CI)

Chemical Property:

• PSA: 35.25000
• LogP: 2.92950

Purity/Quality:

99% ^*data from raw suppliers

5-bromo-2-methoxy-4-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenamine, 5-bromo-2-methoxy-4-methyl- (9CI)

There total 8 articles about Benzenamine, 5-bromo-2-methoxy-4-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-bromo-2-methoxy-4-methylbenzamide (808133-96-2) → 5-bromo-2-methoxy-4-methyl-aniline (808133-98-4)

Guidance literature:

5-bromo-2-methoxy-4-methylbenzamide; With sodium methylate; In methanol;

With bromine; at 5 - 20 ℃; for 1.5h; Heating / reflux;

With potassium hydroxide; In ethanol; for 16h; Heating / reflux;

Reference yield: 60.0%

1-bromo-4-methoxy-2-methyl-5-nitro-benzene (89978-56-3) → 5-bromo-2-methoxy-4-methyl-aniline (808133-98-4)

Guidance literature:

With iron; acetic acid; In water; at 100 ℃; for 4h;

Reference yield:

4-bromo-3-methylanisole (27060-75-9) → 5-bromo-2-methoxy-4-methyl-aniline (808133-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: bismuth (III) nitrate pentahydrate / 1,2-dichloro-ethane / 80 °C

2: acetic acid; iron / water / 4 h / 100 °C

With bismuth (III) nitrate pentahydrate; iron; acetic acid; In water; 1,2-dichloro-ethane;

upstream raw materials:

1-bromo-4-methoxy-2-methyl-5-nitro-benzene

4-bromo-5-methyl-2-nitrophenol

5-bromo-2-methoxy-4-methylbenzamide

4-bromo-3-methylanisole

Downstream raw materials:

2,4-dibromo-5-methylanisole

5-bromo-2-methoxy-4-methylbenzenesulfonyl chloride

Refernces

• 1、 -. "INHIBITORS OF PAPILLOMA VIRUS". Page 47-49. . Retrieved 2008/06/13.