2,6-DIMETHOXY-4-METHYLBENZOIC ACID

Base Information

• Chemical Name: 2,6-DIMETHOXY-4-METHYLBENZOIC ACID
• CAS No.: 20872-08-6
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Mol file: 20872-08-6.mol

Synonyms:2,6-DIMETHOXY-4-METHYLBENZOIC ACID;2,6-DIMETHOXY-P-TOLUIC ACID

Chemical Property of 2,6-DIMETHOXY-4-METHYLBENZOIC ACID

Chemical Property:

• PSA: 55.76000
• LogP: 1.71040

Purity/Quality:

99%min ^*data from raw suppliers

2,6-Dimethoxy-4-methylbenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-DIMETHOXY-4-METHYLBENZOIC ACID

There total 8 articles about 2,6-DIMETHOXY-4-METHYLBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(Hydroxymethyl)-2,6-dimethoxybenzoic acid (131157-39-6) → 2,6-dimethoxy-4-methylbenzoic acid (20872-08-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1248/cpb.38.2118

Reference yield: 72.0%

1,3-dimethoxy-5-methylbenzene (4179-19-5) → 2,6-dimethoxy-4-methylbenzoic acid (20872-08-6)

Guidance literature:

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; hexane;

Reference yield:

3,5-dimethoxybenzyl alcohol (705-76-0) → 2,6-dimethoxy-4-methylbenzoic acid (20872-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, room temperature, 1 h, 2.) room temperature, 2 h

2: 98 percent / hydrogen / 10 percent Pd-C / acetic acid

With n-butyllithium; hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1248/cpb.38.2118

upstream raw materials:

n-butyllithium

diethyl ether

1,3-dimethoxy-5-methylbenzene

2,6-dimethoxy-4-methylbenzaldehyde

Downstream raw materials:

2,6-dimethoxy-4-methyl-benzoic acid methyl ester

2,6-dimethoxy-4-methylbenzoyl chloride

C₁₅H₂₃F₃O₆PdS₂

1,3-dimethoxy-5-methylbenzene

Refernces

• 1、 Ishii,Sugiura,Akiyama,Ichikawa,Watanabe,Murakami. "Fischer indolization and its related compounds. XXIII. Fischer indolization of ethyl pyruvate 2-(2,6-dimethoxyphenyl)phenylhydrazone". . p. 2118 - 2126. Retrieved 2007/10/02.