2-Amino-4-(trifluoromethyl)benzenemethanol

Base Information

• Chemical Name: 2-Amino-4-(trifluoromethyl)benzenemethanol
• CAS No.: 186602-93-7
• Molecular Formula: C₈H₈F₃NO
• Molecular Weight: 191.153
• Mol file: 186602-93-7.mol

Synonyms:2-Amino-4-(trifluoromethyl)benzenemethanol;(2-amino-4-(trifluoromethyl)phenyl)methanol

Chemical Property of 2-Amino-4-(trifluoromethyl)benzenemethanol

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-4-(trifluoromethyl)benzenemethanol

There total 6 articles about 2-Amino-4-(trifluoromethyl)benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-4-trifluoromethylbenzoic acid (402-13-1) → [2-amino-4-(trifluoromethyl)phenyl]methan-1-ol (186602-93-7)

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; for 24h; Heating / reflux;

Reference yield:

(2-nitro-4-(trifluoromethyl)phenyl)methanol (133605-27-3) → [2-amino-4-(trifluoromethyl)phenyl]methan-1-ol (186602-93-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

2-nitro-4-trifluoromethylbenzoic acid (320-94-5) → [2-amino-4-(trifluoromethyl)phenyl]methan-1-ol (186602-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine; t-buthyl chloroformate; sodium borohydride / tetrahydrofuran / 0.02 h / -15 °C

2: hydrogen / Pd-C / tetrahydrofuran / 18 h / 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; hydrogen; tert-butyl chloroformate; palladium on activated charcoal; In tetrahydrofuran;

upstream raw materials:

t-butyl<3-(trifluoromethyl)phenyl>-carbamate

N,N-dimethyl-formamide

(2-nitro-4-(trifluoromethyl)phenyl)methanol

2-nitro-4-trifluoromethylbenzoic acid

Downstream raw materials:

2-amino-4-(trifluoromethyl)benzaldehyde

N-(2-formyl-5-(trifluoromethyl)phenyl)-4-methylbenzenesulfonamide

Refernces

• 1、 Punna, Nagender,Das, Pulakesh,Gouverneur, Véronique,Shibata, Norio. "Highly Diastereoselective Synthesis of Trifluoromethyl Indolines by Interceptive Benzylic Decarboxylative Cycloaddition of Nonvinyl, Trifluoromethyl Benzoxazinanones with Sulfur Ylides under Palladium Catalysis". supporting information. p. 1526 - 1529. Retrieved 2018/03/23.
• 2、 Zhang, Song-Lin,Deng, Zhu-Qin. "Synthesis of quinolines and naphthyridines: Via catalytic retro-aldol reaction of β-hydroxyketones with ortho -aminobenzaldehydes or nicotinaldehydes". supporting information. p. 8966 - 8970. Retrieved 2016/10/05.