2-NITRO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL

Base Information

• Chemical Name: 2-NITRO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL
• CAS No.: 133605-27-3
• Molecular Formula: C8H6F3NO3
• Molecular Weight: 221.136
• Hs Code.: 2906299090
• Mol file: 133605-27-3.mol

Synonyms:2-NITRO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL

Chemical Property of 2-NITRO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL

Chemical Property:

• Melting Point: 63-65℃
• Refractive Index: 1.507
• PSA: 66.05000
• LogP: 2.62910

Purity/Quality:

97% ^*data from raw suppliers

2-Nitro-4-(trifluoromethyl)benzyl alcohol? ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used as important intermediates and reagents in organic synthesis. Also used as solvents.

Technology Process of 2-NITRO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL

There total 4 articles about 2-NITRO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

→ (2-nitro-4-(trifluoromethyl)phenyl)methanol (133605-27-3)

Guidance literature:

Reference yield: 70.0%

2-nitro-4-trifluoromethylbenzoic acid (320-94-5) → (2-nitro-4-(trifluoromethyl)phenyl)methanol (133605-27-3)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b03458

Reference yield:

2-nitro-4-trifluoromethylbenzyl acetate (890434-87-4) → (2-nitro-4-(trifluoromethyl)phenyl)methanol (133605-27-3)

Guidance literature:

With methanol; sodium hydroxide; water; at 20 ℃; for 2h;

upstream raw materials:

2-nitro-4-trifluoromethylbenzoic acid

2-nitro-4-trifluoromethylbenzyl acetate

1-(chloromethyl)-2-nitro-4-(trifluoromethyl)benzene

Downstream raw materials:

1-methoxymethyl-2-nitro-4-trifluoromethylbenzene

1-(bromomethyl)-4-(trifluoromethyl)-2-nitrobenzene

2-methoxymethyl-5-trifluoromethylphenylamine

[2-amino-4-(trifluoromethyl)phenyl]methan-1-ol

Refernces

• 1、 Watts, Field M.,Bunce, Richard A.. "Synthesis of Aryl-Substituted 3,3a,4,5-Tetrahydropyrrolo[1,2- A [ quinolin-1(2 H)-ones and 2,3,4,4a,5,6-Hexahydro-1 H-pyrido[1,2- A [quinolin-1-ones". . p. 564 - 572. Retrieved 2019/01/10.
• 2、 Palanki, Moorthy S.S.,Erdman, Paul E.,Goldman, Mark E.,Suto, Carla,Suto, Mark J.. "Synthesis and structure-activity relationship studies of conformationally restricted, analogs of 2-chloro-4-trifluoromethylpyrimidine- 5-[N-(3',5'-bis(trifluoromethyl)phenyl)]carboxamide". . p. 19 - 29. Retrieved 2007/10/03.