Technology Process of 6-CHLORO-4-O-TOLYL-NICOTINAMIDE
There total 3 articles about 6-CHLORO-4-O-TOLYL-NICOTINAMIDE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-chloro-4-o-tolyl-nicotinic acid;
With
thionyl chloride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 50 ℃;
for 2h;
With
ammonium hydroxide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
at 0 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 19 h / 0 - 20 °C
1.2: acetic acid / tetrahydrofuran / -60 °C
1.3: Mn(OAc)3*2H2O / tetrahydrofuran / 1.5 h / -60 - 20 °C
2.1: SOCl2; DMF / tetrahydrofuran / 2.5 h / 50 °C
3.1: 7.8 g / NH3 / tetrahydrofuran; H2O / 0.5 h / 0 °C
With
thionyl chloride; ammonia; N,N-dimethyl-formamide;
In
tetrahydrofuran; water;
1.1: Grignard addition;
DOI:10.1021/jo0523666
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 19 h / 0 - 20 °C
1.2: acetic acid / tetrahydrofuran / -60 °C
1.3: Mn(OAc)3*2H2O / tetrahydrofuran / 1.5 h / -60 - 20 °C
2.1: SOCl2; DMF / tetrahydrofuran / 2.5 h / 50 °C
3.1: 7.8 g / NH3 / tetrahydrofuran; H2O / 0.5 h / 0 °C
With
thionyl chloride; ammonia; N,N-dimethyl-formamide;
In
tetrahydrofuran; water;
1.1: Grignard addition;
DOI:10.1021/jo0523666
