Methyl 2-(aMinoMethyl)-5-fluorobenzoate hydrochloride

Base Information

• Chemical Name: Methyl 2-(aMinoMethyl)-5-fluorobenzoate hydrochloride
• CAS No.: 606080-44-8
• Molecular Formula: C9H11ClFNO2
• Molecular Weight: 219.643
• Mol file: 606080-44-8.mol

Synonyms:Methyl 2-(aMinoMethyl)-5-fluorobenzoate hydrochloride;BENZOIC ACID, 2-(AMINOMETHYL)-5-FLUORO-, METHYL ESTER, HYDROCHLORIDE(1:1)

Chemical Property of Methyl 2-(aMinoMethyl)-5-fluorobenzoate hydrochloride

Chemical Property:

• PSA: 52.32000
• LogP: 2.57330

Purity/Quality:

99%min ^*data from raw suppliers

Methyl2-(aminomethyl)-5-fluorobenzoateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(aMinoMethyl)-5-fluorobenzoate hydrochloride

There total 5 articles about Methyl 2-(aMinoMethyl)-5-fluorobenzoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-cyano-5-fluorobenzoate (606080-43-7) → methyl-2-(aminomethyl)-5-fluorobenzoate hydrochloride (606080-44-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; at 40 ℃; for 48h; under 2327.23 Torr;

Reference yield:

C9H8FN3O2 → methyl-2-(aminomethyl)-5-fluorobenzoate hydrochloride (606080-44-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; water; at 20 ℃; for 2.5h; under 760.051 Torr;

Reference yield:

methyl 2-(bromomethyl)-5-fluorobenzoate (138786-65-9) → methyl-2-(aminomethyl)-5-fluorobenzoate hydrochloride (606080-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / methanol; water / 2 h / 20 °C / Heating / reflux

2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol; water / 2.5 h / 20 °C / 760.05 Torr

With hydrogenchloride; sodium azide; hydrogen; palladium 10% on activated carbon; In methanol; water;

upstream raw materials:

methyl 2-cyano-5-fluorobenzoate

methyl 2-(bromomethyl)-5-fluorobenzoate

C₁₉H₂₆FNO₆

5-fluoro-2-methylbenzoic acid methyl ester

Downstream raw materials:

methyl 2-((tert-butoxycarbonylamino)methyl)-5-fluorobenzoate

Refernces

• 1、 -. "COMPOUNDS FOR TREATING VIRAL INFECTIONS". . . Retrieved 2008/12/08.