METHYL 2-METHYL-5-FLUOROBENZOATE

Base Information

• Chemical Name: METHYL 2-METHYL-5-FLUOROBENZOATE
• CAS No.: 175278-29-2
• Molecular Formula: C9H9FO2
• Molecular Weight: 168.168
• Hs Code.: 2916399090
• Mol file: 175278-29-2.mol

Synonyms:Methyl 5-fluoro-2-methylbenzoate;benzoic acid, 5-fluoro-2-methyl-, methyl ester;methyl 5-fluoro-2-methylbenzoate;

Chemical Property of METHYL 2-METHYL-5-FLUOROBENZOATE

Chemical Property:

• Vapor Pressure: 0.178mmHg at 25°C
• Refractive Index: 1.491
• Boiling Point: 211.898 °C at 760 mmHg
• Flash Point: 79.884 °C
• PSA: 26.30000
• Density: 1.138 g/cm³
• LogP: 1.92070
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl5-Fluoro-2-MethylBenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-METHYL-5-FLUOROBENZOATE

There total 3 articles about METHYL 2-METHYL-5-FLUOROBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-fluoro-2-methylbenzoic acid (33184-16-6) + methyl iodide (74-88-4) → 5-fluoro-2-methylbenzoic acid methyl ester (175278-29-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2010.06.134

Reference yield: 89.0%

methanol (67-56-1) + 5-fluoro-2-methylbenzoic acid (33184-16-6) → 5-fluoro-2-methylbenzoic acid methyl ester (175278-29-2)

Guidance literature:

With sulfuric acid; at 60 ℃;

Reference yield: 78.0%

5-fluoro-2-methylbenzoic acid (33184-16-6) → 5-fluoro-2-methylbenzoic acid methyl ester (175278-29-2)

Guidance literature:

With sulfuric acid; In methanol;

upstream raw materials:

methanol

5-fluoro-2-methylbenzoic acid

methyl iodide

Downstream raw materials:

methyl 2-(bromomethyl)-5-fluorobenzoate

3-(5-fluoro-2-methylphenyl)-3-oxopropanenitrile

methyl 3-bromo-5-fluoro-2-methylbenzoate

methyl-2-(aminomethyl)-5-fluorobenzoate hydrochloride

Refernces

• 1、 -. "Aromatic ring-containing compound and application thereof". Paragraph 0126-0131. . Retrieved 2019/10/01.
• 2、 Lin, Jinguan,Houpis, Ioannis N.,Liu, Renmao,Wang, Youchu,Zhang, Jianqian. "Copper-catalyzed C-N coupling in the synthesis of integrase inhibitors of immunodeficiency viruses". . p. 205 - 214. Retrieved 2014/05/20.