2-METHYL-5-FLUOROBENZOYLACETONITRILE

Base Information

• Chemical Name: 2-METHYL-5-FLUOROBENZOYLACETONITRILE
• CAS No.: 884504-23-8
• Molecular Formula: C₁₀H₈FNO
• Molecular Weight: 177.178
• Mol file: 884504-23-8.mol

Synonyms:2-METHYL-5-FLUOROBENZOYLACETONITRILE;5-FLUORO-2-METHYLBENZOYLACETONITRILE

Chemical Property of 2-METHYL-5-FLUOROBENZOYLACETONITRILE

Chemical Property:

• Vapor Pressure: 0.000379mmHg at 25°C
• Boiling Point: 317.7°C at 760 mmHg
• Flash Point: 145.9°C
• Density: 1.17g/cm³

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-5-fluorobenzoylacetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-5-FLUOROBENZOYLACETONITRILE

There total 1 articles about 2-METHYL-5-FLUOROBENZOYLACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

5-fluoro-2-methylbenzoic acid methyl ester (175278-29-2) + acetonitrile (75-05-8,26809-02-9) → 3-(5-fluoro-2-methylphenyl)-3-oxopropanenitrile (884504-23-8)

Guidance literature:

acetonitrile; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1.03333h; Inert atmosphere;

5-fluoro-2-methylbenzoic acid methyl ester; In tetrahydrofuran; at -78 - 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c01777

upstream raw materials:

5-fluoro-2-methylbenzoic acid methyl ester

acetonitrile

Refernces

• 1、 -. "COMPOUNDS AND METHODS FOR TREATING CANCER". Paragraph 0228. . Retrieved 2020/11/30.