175278-29-2

Basic information

• Product Name: METHYL 2-METHYL-5-FLUOROBENZOATE
• Synonyms: RARECHEM AL BF 0505;METHYL 2-METHYL-5-FLUOROBENZOATE;METHYL 5-FLUORO-2-METHYLBENZOATE;5-fluoro-2-methylbenzoate
• CAS NO: 175278-29-2
• Molecular Formula: C₉H₉FO₂
• Molecular Weight: 168.16
• Mol File: 175278-29-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 90-92°C 15mm
• Flash Point: 79.884 °C
• Appearance: /
• Density: 1.138 g/cm³
• Vapor Pressure: 0.178mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 2-METHYL-5-FLUOROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-METHYL-5-FLUOROBENZOATE(175278-29-2)
• EPA Substance Registry System: METHYL 2-METHYL-5-FLUOROBENZOATE(175278-29-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 175278-29-2(Hazardous Substances Data)

Usage

General Description

Methyl 2-Methyl-5-Fluorobenzoate is a chemical compound often used in the field of organic synthesis or as a pharmaceutical intermediate. Its molecular formula is C9H9FO2 and it appears as a clear liquid or white solid. Being an organic ester, it is susceptible to hydrolysis in the presence of acids or bases. It is also flammable, and care must be taken when handling to prevent exposure to open flame or high heat. Despite its frequent use in industry, little is currently known about its potential toxicity or environmental impact.

InChI:InChI=1/C9H9FO2/c1-6-3-4-7(10)5-8(6)9(11)12-2/h3-5H,1-2H3

Upstream product

• 67-56-1 methanol 
• 33184-16-6 5-fluoro-2-methylbenzoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 884504-23-8 3-(5-fluoro-2-methylphenyl)-3-oxopropanenitrile 
• 1187318-53-1 methyl 3-bromo-5-fluoro-2-methylbenzoate 
• 606080-44-8 methyl-2-(aminomethyl)-5-fluorobenzoate hydrochloride 
• 1082040-43-4 6-fluoro-1H-indole-4-carboxylic acid methyl ester 
• 697739-03-0 5-fluoro-2-methyl-3-nitrobenzoic acid methyl ester 
• 138786-63-7 2-(5-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-tetrazol-2-ylmethyl)-5-fluoro-benzoic acid 
• 606080-42-6 5-(1,1-dioxido-1,2-thiazinan-2-yl)-N-{4-fluoro-2-[(methylamino)carbonyl]benzyl}-8-hydroxy-1,6-naphthyridine-7-carboxamide 
• 569354-60-5 N-methyl 2-aminomethyl-5-fluorobenzenecarboxamide HCl salt 
• 569354-58-1 C₁₉H₂₆FNO₆ 
• 569354-59-2 N-methyl 2-t-butyloxycarbonylaminomethyl-5-fluorobenzenecarboxamide 
• 138786-65-9 methyl 2-(bromomethyl)-5-fluorobenzoate 

Relevant articles and documents

Copper-promoted direct amidation of isoindolinone scaffolds by sodium persulfate

Isoindolinones are ubiquitous structural motifs in natural products and pharmaceuticals. Establishing an efficient method for structural modification of isoindolinones could significantly facilitate new drug development. Herein, we describe copper-promoted direct amidation of isoindolinone scaffolds mediated by sodium persulfate. The method exhibits mild reaction conditions and high site-selectivity, and enables the structural modification of the drug indobufen ester with various amides with yields of 49 to 98%. It is also gram-scalable. Additionally, the reaction mechanism appears to involve a radical and a carbocationic pathway.

Preparation method of ovarian cancer resistance medicine Rucaparib key intermediate

The invention discloses a preparation method of an ovarian cancer resistance medicine Rucaparib key intermediate, and relates to preparation of medical intermediates. A compound 1 takes methyl alcoholand cyclohexane as solvents, toluenesulfonic acid serve

Biaryl substituted hydantoin compounds as TACE inhibitors

We disclose further optimization of hydantoin TNF-α convertase enzyme (TACE) inhibitors. SAR with respect to the non-prime region of TACE active site was explored. A series of biaryl substituted hydantoin compounds was shown to have sub-nanomolar Ki