569354-59-2

Basic information

• Product Name: Carbamic acid, [[4-fluoro-2-[(methylamino)carbonyl]phenyl]methyl]-, 1,1-dimethylethyl ester
• CAS NO: 569354-59-2
• Molecular Formula: C14H19FN2O3
• Molecular Weight: 282.315
• Mol File: 569354-59-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [[4-fluoro-2-[(methylamino)carbonyl]phenyl]methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [[4-fluoro-2-[(methylamino)carbonyl]phenyl]methyl]-, 1,1-dimethylethyl ester(569354-59-2)
• EPA Substance Registry System: Carbamic acid, [[4-fluoro-2-[(methylamino)carbonyl]phenyl]methyl]-, 1,1-dimethylethyl ester(569354-59-2)

Safety Data

• Hazardous Substances Data: 569354-59-2(Hazardous Substances Data)

Upstream product

• 394-28-5 2-Bromo-5-fluorobenzoic acid 
• 606080-45-9 methyl 2-((tert-butoxycarbonylamino)methyl)-5-fluorobenzoate 
• 74-89-5 methylamine 
• 138786-65-9 methyl 2-(bromomethyl)-5-fluorobenzoate 
• 175278-29-2 5-fluoro-2-methylbenzoic acid methyl ester 
• 569354-58-1 C₁₉H₂₆FNO₆ 

Downstream Products

• 606080-42-6 5-(1,1-dioxido-1,2-thiazinan-2-yl)-N-{4-fluoro-2-[(methylamino)carbonyl]benzyl}-8-hydroxy-1,6-naphthyridine-7-carboxamide 
• 569354-60-5 N-methyl 2-aminomethyl-5-fluorobenzenecarboxamide HCl salt 

Relevant articles and documents

HIV integrase inhibitors

The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

Preparation of 2-aminomethyl-5-fluorobenzamides

Benzamide compounds of Formula VII are prepared by reacting a benzoate compound of Formula V with an amine to obtain a benzamide compound of Formula VI, and then treating the benzamide VI with an amine deprotecting agent to obtain the benzamide VII; where