Clenproperol

Base Information

• Chemical Name: Clenproperol
• CAS No.: 1173021-09-4
• Molecular Formula: C₁₁H₁₆Cl₂N₂O
• Molecular Weight: 270.111
• Mol file: 1173021-09-4.mol

Synonyms:Clenproperol-d7

Chemical Property of Clenproperol

Chemical Property:

• Melting Point: 109-111°C
• PSA: 58.28000
• LogP: 3.57910
• Storage Temp.: -20?C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

Clenproperol-d7 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A labelled related drug A labelled related drug of Clenbuterol (C569998), a β-agonist which can be used as a growth promoter in farm animals.

Technology Process of Clenproperol

There total 6 articles about Clenproperol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

D7-1-(4-amino-3,5-dichloro)-2-isopropylaminoethanone → D7-clenproperol (1173021-09-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield: 57.4%

[(2)H6]acetone (666-52-4) + 4-amino-α-(aminomethyl)-3,5-dichlorobenzenemethanol (38339-07-0) → D7-clenproperol (1173021-09-4)

Guidance literature:

[⁽²⁾H₆]acetone; 4-amino-α-(aminomethyl)-3,5-dichlorobenzenemethanol; With d⁽⁴⁾-methanol; at 20 ℃; for 2h;

With sodium borodeuteride; at 20 ℃; for 14h;

Reference yield:

1-(4-amino-3,5-dichlorophenyl)-1-ethanone (37148-48-4) → D7-clenproperol (1173021-09-4)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / 3 h / 20 °C

2: 3 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

With lithium aluminium tetrahydride; bromine; In tetrahydrofuran;

upstream raw materials:

2,6-Dichloroaniline

1-(4-amino-3,5-dichlorophenyl)-1-ethanone

[⁽²⁾H₆]acetone

4-amino-α-(aminomethyl)-3,5-dichlorobenzenemethanol

Refernces

• 1、 -. "Stable isotope labeling Clenproperol compound and synthesis method thereof". . . Retrieved 2018/02/04.