AKOS BBS-00002550

Base Information

• Chemical Name: AKOS BBS-00002550
• CAS No.: 21517-30-6
• Molecular Formula: C₉H₈N₆
• Molecular Weight: 200.203
• Hs Code.: 2933990090
• Mol file: 21517-30-6.mol

Synonyms:AKOS BBS-00002550;CHEMBRDG-BB 4102438;6-HYDRAZINO[1,2,4]TRIAZOLO[3,4-A]PHTHALAZINE;6-hydrazino[1,2,4]triazolo[3,4-a]phthalazine(SALTDATA: FREE)

Chemical Property of AKOS BBS-00002550

Chemical Property:

• Melting Point: 299-301 °C
• Boiling Point: 546.2±33.0 °C(Predicted)
• PKA: 1.90±0.20(Predicted)
• PSA: 81.13000
• Density: 1.69g/cm³
• LogP: 1.33640

Purity/Quality:

99% ^*data from raw suppliers

6-hydrazino[1,2,4]triazolo[3,4-a]phthalazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS BBS-00002550

There total 5 articles about AKOS BBS-00002550 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6-chloro-1,2,4-triazolo<3,4-a>phthalazine (52494-53-8) → 6-hydrazinyl-[1,2,4]triazolo[3,4-a]phthalazine (21517-30-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 0.5h; Reflux;

DOI:10.1002/ardp.201700240

Reference yield:

formic acid-(N'-[1,2,4]triazolo[3,4-a]phthalazin-6-ylhydrazide) (116605-58-4) → 6-hydrazinyl-[1,2,4]triazolo[3,4-a]phthalazine (21517-30-6)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jo01091a010

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + phthalonitrile (91-15-6) → 6-hydrazinyl-[1,2,4]triazolo[3,4-a]phthalazine (21517-30-6)

Guidance literature:

With hydrazine hydrate;

upstream raw materials:

formic acid-(N'-[1,2,4]triazolo[3,4-a]phthalazin-6-ylhydrazide)

N,N-dimethyl-formamide

phthalonitrile

formic acid

Refernces

• 1、 El-Helby, Abdel-Ghany A.,Ayyad, Rezk R. A.,Sakr, Helmy,El-Adl, Khaled,Ali, Mamdouh M.,Khedr, Fathalla. "Design, Synthesis, Molecular Docking, and Anticancer Activity of Phthalazine Derivatives as VEGFR-2 Inhibitors". . . Retrieved 2017/11/20.