Technology Process of (R)-2-AMino-1-(pyridin-3-yl)ethanol hydrochloride
There total 4 articles about (R)-2-AMino-1-(pyridin-3-yl)ethanol hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
borane-(R)-2-chloro-1-(3-pyridinyl)ethanol;
With
ammonium hydroxide;
In
methanol; water;
at 25 ℃;
for 18h;
Large scale;
With
hydrogenchloride;
In
water;
at 10 ℃;
for 0.166667h;
Large scale;
DOI:10.1021/op0340208
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / tetrahydrofuran / 1 h / 17 °C
2.1: (R)-α,α-diphenylprolinol; dimethylsulfide borane complex; Trimethyl borate / tetrahydrofuran / 12.3 h / 25 °C / Large scale
2.2: 2 h / 25 °C / Large scale
3.1: ammonium hydroxide / water; methanol / 18 h / 25 °C / Large scale
3.2: 0.17 h / 10 °C / Large scale
With
ammonium hydroxide; Trimethyl borate; dimethylsulfide borane complex; (R)-α,α-diphenylprolinol; triethylamine;
In
tetrahydrofuran; methanol; water;
DOI:10.1021/op0340208
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; N-chloro-succinimide / acetic acid / 20 °C / Large scale
2.1: triethylamine / tetrahydrofuran / 1 h / 17 °C
3.1: (R)-α,α-diphenylprolinol; dimethylsulfide borane complex; Trimethyl borate / tetrahydrofuran / 12.3 h / 25 °C / Large scale
3.2: 2 h / 25 °C / Large scale
4.1: ammonium hydroxide / water; methanol / 18 h / 25 °C / Large scale
4.2: 0.17 h / 10 °C / Large scale
With
hydrogenchloride; ammonium hydroxide; N-chloro-succinimide; Trimethyl borate; dimethylsulfide borane complex; (R)-α,α-diphenylprolinol; triethylamine;
In
tetrahydrofuran; methanol; water; acetic acid;
DOI:10.1021/op0340208
