61889-48-3

Basic information

• Product Name: 3-(2-Chloroacetyl)pyridine hydrochloride
• Synonyms: 3-(2-Chloroacetyl)pyridine hydrochloride;Ketone, chloromethyl-3-pyridyl, hydrochloride;Nsc77639;2-chloro-1-(3-pyridinyl)ethanone hydrochloride;3-(2-Chloroacetyl)pyridine HCl;2-CHLORO-1-(PYRIDIN-3-YL)ETHANONE HCL
• CAS NO: 61889-48-3
• Molecular Formula: C7H6ClNO
• Molecular Weight: 155.58
• Mol File: 61889-48-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 245-250 °C (decomp)
• Boiling Point: 272.4 °C at 760 mmHg
• Flash Point: 118.5 °C
• Appearance: /
• Density: 1.238 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-(2-Chloroacetyl)pyridine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Chloroacetyl)pyridine hydrochloride(61889-48-3)
• EPA Substance Registry System: 3-(2-Chloroacetyl)pyridine hydrochloride(61889-48-3)

Safety Data

• Hazardous Substances Data: 61889-48-3(Hazardous Substances Data)

Usage

Uses

3-(2-Chloroacetyl)pyridine Hydrochloride is used in the synthetic preparation of chiral amino(pyridinyl)ethanol via lipase-mediated kinetic resolution.

InChI:InChI=1/C7H6ClNO/c8-4-7(10)6-2-1-3-9-5-6/h1-3,5H,4H2

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 67210-10-0 nicotinoyl chloride hydrochloride 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 59-67-6 nicotinic acid 
• 39972-50-4 2-diazo-1-(pyridine-3-yl)ethan-1-one 

Downstream Products

• 515179-33-6 (S)-2-chloro-1-(pyridin-3-yl)ethanol 
• 173901-03-6 (R)-2-chloro-1-(3-pyridyl)-ethanol 
• 55484-11-2 2-chloro-1-(pyridin-3-yl)ethan-1-one 
• 1038594-01-2 (1R)-2-amino-1-(3-pyridinyl)ethanol dihydrochloride 

Relevant articles and documents

NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS

This invention relates to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.

A scalable asymmetric synthesis of (R)-2-amino-1-(3-pyridinyl)ethanol dihydrochloride via an oxazaborolidine catalyzed borane reduction

This report describes a scalable process for the asymmetric synthesis of (R)-2-amino-1-(3-pyridinyl)ethanol dihydrochloride. The stereochemistry of the product is set via a reduction of 3-chloroacetyl pyridine with 2 equiv of borane-dimethyl sulfide and a catalytic amount of an in situ generated oxazaborolidine. The enantiomeric excess (ee) of the reductive step depends on the addition rate of the substrate and the temperature. The authors hypothesize that the low ee observed during a fast addition of the substrate or at low temperatures is due to the slow regeneration of the active catalyst from the catalyst-product complex.

CARBOXYL SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA 3 ADRENORECEPTOR AGONISTS

This invention is related to novel carboxyl substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.