515179-33-6 Usage
Description
(S)-2-chloro-1-(pyridin-3-yl)ethanol is an organic compound characterized by its unique structure, featuring a chloro group at the 2nd carbon and a pyridin-3-yl group at the 1st carbon. (S)-2-chloro-1-(pyridin-3-yl)ethanol is notable for its distinct stereochemistry, with the "S" configuration indicating the spatial arrangement of its atoms. It is a valuable intermediate in the synthesis of various pharmaceuticals and other specialty chemicals due to its versatile functional groups and potential for further chemical reactions.
Uses
Used in Pharmaceutical Synthesis:
(S)-2-chloro-1-(pyridin-3-yl)ethanol is used as a key intermediate in the synthesis of chiral amino(pyridinyl)ethanol, which is an important building block for the development of pharmaceuticals with potential applications in various therapeutic areas. (S)-2-chloro-1-(pyridin-3-yl)ethanol's unique structure allows for the creation of novel drugs with improved efficacy and selectivity.
Used in Enzymatic Reactions:
In the field of biocatalysis, (S)-2-chloro-1-(pyridin-3-yl)ethanol is utilized in lipase-mediated kinetic resolution processes. This enzymatic approach enables the selective transformation of racemic mixtures into their individual enantiomers, which are crucial for the development of enantiomerically pure drugs. The use of biocatalysts like lipases offers a more sustainable and environmentally friendly alternative to traditional chemical synthesis methods, as it often requires milder reaction conditions and generates fewer byproducts.
Used in Chemical Research:
(S)-2-chloro-1-(pyridin-3-yl)ethanol serves as a valuable research tool for chemists working on the development of new synthetic methods, asymmetric catalysis, and novel chiral ligands. Its unique structure and reactivity make it an attractive candidate for exploring new reaction pathways and understanding the underlying mechanisms of various chemical transformations.
Check Digit Verification of cas no
The CAS Registry Mumber 515179-33-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,1,5,1,7 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 515179-33:
(8*5)+(7*1)+(6*5)+(5*1)+(4*7)+(3*9)+(2*3)+(1*3)=146
146 % 10 = 6
So 515179-33-6 is a valid CAS Registry Number.
515179-33-6Relevant articles and documents
NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS
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Page/Page column 27, (2008/12/07)
This invention relates to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2- aminoethanol, valuable moiety of β3-adrenergic receptor agonists
Perrone, Maria Grazia,Santandrea, Ernesto,Giorgio, Erika,Bleve, Laura,Scilimati, Antonio,Tortorella, Paolo
, p. 1207 - 1214 (2007/10/03)
Enantiomerically pure (R)-2-chloro-1-(pyridin-3-yl)ethanol has been prepared by kinetic resolution performed in the presence of Candida antarctica SP435-L lipase immobilized on a macroporous polyacrylate resin (Novozym 435). It was converted into (R)-1-(pyridin-3-yl)-2-aminoethanol, left-hand side of β3-adrenergic receptor ligands.
PROCESS TO PRODUCE ENANTIOMERICALLY ENRICHED 1-ARYL- AND 1-HETEROARYL-2-AMINOETHANOLS
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Page 28, (2008/06/13)
The invention relates to a method of preparing enantiomerically enriched amino alcohols of Formula (I) wherein the variable R1, R2, and R3 are defined herein.
