2-(4-Methoxyphenyl)-2-phenylacetaldehyde

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-2-phenylacetaldehyde
• CAS No.: 16343-36-5
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Mol file: 16343-36-5.mol

Synonyms:2-(4-Methoxyphenyl)-2-phenylacetaldehyde

Chemical Property of 2-(4-Methoxyphenyl)-2-phenylacetaldehyde

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Methoxyphenyl)-2-phenylacetaldehyde

There total 34 articles about 2-(4-Methoxyphenyl)-2-phenylacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

trans-(2R,3R)-2-phenyl-3-(4-(trifluoromethoxy)phenyl)oxirane (5814-81-3,14802-05-2,67042-23-3,70288-32-3,70332-47-7) → 2-(4-methoxy-phenyl)-2-phenylacetaldehyde (16343-36-5)

Guidance literature:

With copper(II) tetrafluoroborate hydrate; In dichloromethane; for 2.5h; regioselective reaction; Reflux;

DOI:10.1016/j.tet.2010.08.078

Reference yield: 90.0%

1-methoxy-4-(2-methoxy-1-phenylvinyl)benzene → 2-(4-methoxy-phenyl)-2-phenylacetaldehyde (16343-36-5)

Guidance literature:

With sulfuric acid; sodium iodide; In 1,4-dioxane; water; at 50 ℃;

DOI:10.1021/ja029139v

Reference yield: 80.0%

1-(4-methoxyphenyl)-2-phenyl-ethane-1,2-diol (109337-44-2) → 2-(4-methoxy-phenyl)-2-phenylacetaldehyde (16343-36-5)

Guidance literature:

With iron(III) chloride hexahydrate; N-fluorobis(benzenesulfon)imide; In neat (no solvent); Microwave irradiation;

DOI:10.1021/acs.joc.7b02587

upstream raw materials:

1-(4-methoxyphenyl)-1-phenylethene

2-(4-methoxyphenyl)-2-phenyloxirane

3-(4-Methoxyphenyl)-1,1,3-triphenylpropene

1-(4-methoxyphenyl)-2-phenyl-ethane-1,2-diol

Downstream raw materials:

4-Methoxybenzophenone

1-(4-methoxyphenyl)-1-phenylethene

2-(4-methoxyphenyl)-1,2-diphenylethan-1-one

2-(4-methoxyphenyl)-2-phenylethanol

Refernces

• 1、 Tiwari, Praveen Kumar,Sivaraman, Balasubramaniam,Aidhen, Indrapal Singh. "α,α-Diarylethylene Glycols as Valuable Precursor for Synthesis of 1,1-Diarylethenes and α,α-Diaryl Acetaldehydes". supporting information. p. 3594 - 3605. Retrieved 2017/07/22.
• 2、 Jamalian, Arezu,Rathman, Benjamin,Borosky, Gabriela L.,Laali, Kenneth K.. "Catalytic, regioselective, and green methods for rearrangement of 1,2-diaryl epoxides to carbonyl compounds employing metallic triflates, Br?nsted-acidic ionic liquids (ILs), and IL/microwave; experimental and computational substituent effect study on aryl versus hydrogen migration". . p. 1 - 11. Retrieved 2015/09/28.