Solvent Blue 8

Base Information

• Chemical Name: Solvent Blue 8
• CAS No.: 12262-49-6
• Molecular Formula: C16H18ClN3S
• Molecular Weight: 319.85222
• Mol file: 12262-49-6.mol

Synonyms:Solvent Blue 8;7-(dimethylamino)-3-(methylimino)-3h-phenothiazin 3-methochloride;aizen methylene blue bh;aizen methylene blue fz;basic lake blue;Basic turquoise BB;bleu de methylene;C.I.Solvent Blue 8

Chemical Property of Solvent Blue 8

Chemical Property:

• PSA: 47.38000
• LogP: -0.49710
• Water Solubility.: 40 g/L (20℃)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xn:Harmful
• Statements: R22:; R41:
• Safety Statements: S26:; S39:

MSDS Files:

Useful:

Technology Process of Solvent Blue 8

There total 32 articles about Solvent Blue 8 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3,11-dinitro-10H-phenothiazine (1747-90-6) → methylene blue (152071-32-4,105504-42-5,121067-62-7,12262-49-6,167498-52-4,6476-03-5,97130-83-1)

Guidance literature:

formaldehyd; 3,11-dinitro-10H-phenothiazine; With 5%-palladium/activated carbon; hydrogen; In water; N,N-dimethyl-formamide; at 20 - 90 ℃; for 18h; under 2850.29 - 45079.5 Torr;

With hydrogenchloride; iron(III) chloride hexahydrate; In water; N,N-dimethyl-formamide; at 5 ℃; for 2.5h; Time; Pressure; Concentration;

Reference yield: 52.0%

1-[3,7-bis(dimethylamino)phenothiazin-10-yl]ethanone (3763-06-2) → methylene blue (152071-32-4,105504-42-5,121067-62-7,12262-49-6,167498-52-4,6476-03-5,97130-83-1)

Guidance literature:

1-[3,7-bis(dimethylamino)phenothiazin-10-yl]ethanone; With hydrogenchloride; In water; at 80 ℃; for 1h;

With iron(III) chloride; In water; at 5 - 25 ℃; for 0.166667 - 0.5h; Product distribution / selectivity;

Reference yield: 51.72%

(4-(2-(thiosulfate)-4-(dimethylamino)-phenylimino)-cyclohex-2,5-dienylidene)-N,N-dimethyl ammonium (15967-15-4) → methylene blue (152071-32-4,105504-42-5,121067-62-7,12262-49-6,167498-52-4,6476-03-5,97130-83-1)

Guidance literature:

With copper(II) sulfate; at 90 ℃; for 1h;

upstream raw materials:

(4-(2-(thiosulfate)-4-(dimethylamino)-phenylimino)-cyclohex-2,5-dienylidene)-N,N-dimethyl ammonium

4-amino-N,N-dimethylaniline

p-dimethylaminonitrosobenzene

Leuco-Methylenblau

Downstream raw materials:

semi-reduced methylene blue

phenylnitrenium ion

tetrathionic acid

azure A

Refernces

• 1、 -. "A PROCESS FOR THE PREPARATION OF METHYLENE BLUE". . . Retrieved 2021/09/04.
• 2、 Jia, Xu,Wei, Chao,Li, Zimeng,Liu, Liyan,Wang, Mei,Zhang, Pingzhu,Li, Xiaoliu. "Selective Imaging of HClO in the Liver Tissue In Vivo Using a Near-infrared Hepatocyte-specific Fluorescent Probe". . p. 1967 - 1972. Retrieved 2021/06/14.