2-Methyl-9H-carbazole

Base Information

• Chemical Name: 2-Methyl-9H-carbazole
• CAS No.: 3652-91-3
• Molecular Formula: C13H11 N
• Molecular Weight: 181.237
• Hs Code.: 2933990090
• European Community (EC) Number: 222-894-3
• NSC Number: 10153
• UNII: 7MWG08F2MG
• DSSTox Substance ID: DTXSID9073963
• Nikkaji Number: J46.571B
• Wikidata: Q27268584
• ChEMBL ID: CHEMBL1173640
• Mol file: 3652-91-3.mol

Synonyms:2-Methyl-9H-carbazole;2-METHYLCARBAZOLE;3652-91-3;9H-Carbazole, 2-methyl-;Carbazole, 2-methyl-;2-Methyldibenzopyrrole;27323-29-1;UNII-7MWG08F2MG;7MWG08F2MG;CHEMBL1173640;EINECS 222-894-3;NSC 10153;NSC-10153;2-methyl carbazole;NSC10153;2-methyl-9H-carbazol;9H-Carbazole, methyl-;D0RO7K;2-Methyl-9H-carbazole #;SCHEMBL607346;DTXSID9073963;BCP31713;BDBM50322581;MFCD00061082;AKOS006274371;1-Methylcarbazole;SY265428;FT-0691792;E83748;Q27268584

Chemical Property of 2-Methyl-9H-carbazole

Chemical Property:

• Vapor Pressure: 2.59E-05mmHg at 25°C
• Melting Point: 259 °C
• Boiling Point: 369.1°Cat760mmHg
• PKA: 17.15±0.30(Predicted)
• Flash Point: 165.4°C
• PSA: 15.79000
• Density: 1.19g/cm³
• LogP: 3.62950
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 181.089149355
• Heavy Atom Count: 14
• Complexity: 213

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)C3=CC=CC=C3N2

Technology Process of 2-Methyl-9H-carbazole

There total 76 articles about 2-Methyl-9H-carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-methyl-2'-nitrobiphenyl (70680-21-6) → 2-methyl-9H-carbazole (3652-91-3)

Guidance literature:

With triphenylphosphine; In 1,2-dichloro-benzene; at 20 ℃; for 6h; Reflux;

DOI:10.1016/j.tet.2019.01.003

Reference yield: 93.0%

N-(4′-methyl-[1,1′-biphenyl]-2-yl)picolinamide (1609211-12-2) → 2-methyl-9H-carbazole (3652-91-3)

Guidance literature:

With manganese(IV) oxide; copper diacetate; acetic acid; In N,N-dimethyl-formamide; at 200 ℃; for 1h; Microwave irradiation; Sealed tube;

DOI:10.1021/ol501037j

Reference yield: 91.0%

2-methyl-9-benzenesulfonylcarbazole (116325-34-9) → 2-methyl-9H-carbazole (3652-91-3)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 60 ℃; for 6h;

DOI:10.1021/ja111652v

upstream raw materials:

2-methyl-1H-indole

methyl vinyl ketone

hydroquinone

7-methyl-2,3,4,9-tetrahydro-1H-carbazole

Downstream raw materials:

9-benzoyl-2-methylcarbazole

2-methyl-9-benzenesulfonylcarbazole

9-benzoyl-2-bromomethylcarbazole

2-Acetylamino-2-(9-benzoyl-9H-carbazol-2-ylmethyl)-malonic acid diethyl ester

Refernces

• 1、 Moskovkina,Pyanzin,Isakov. "New one stage synthesis of 3,3′-bis(2-methylindolyl)methane - A homolog of the marine antibiotic vibriindole [4]". . p. 259 - 260. Retrieved 2001.
• 2、 Steingruber, H. Sebastián,Mendioroz, Pamela,Volpe, María A.,Gerbino, Darío C.. "Convenient One-Pot Synthesis of 9 H -Carbazoles by Microwave Irradiation Employing a Green Palladium-Based Nanocatalyst". . p. 4048 - 4058. Retrieved 2021/08/03.
• 3、 -. "Preparation of 2 - substituted oxazole compounds". Paragraph 0031; 0032. . Retrieved 2018/02/28.