2-(4-Ethoxyphenyl)-2-methylpropan-1-ol

Base Information

• Chemical Name: 2-(4-Ethoxyphenyl)-2-methylpropan-1-ol
• CAS No.: 83493-63-4
• Molecular Formula: C12H18O2
• Molecular Weight: 194.274
• Hs Code.: 2909499000
• European Community (EC) Number: 680-130-8
• DSSTox Substance ID: DTXSID60232401
• Nikkaji Number: J2.650.628J
• Wikidata: Q27119828
• Metabolomics Workbench ID: 56256
• Mol file: 83493-63-4.mol

Synonyms:83493-63-4;2-(4-Ethoxyphenyl)-2-methylpropanol;2-(4-ethoxyphenyl)-2-methylpropan-1-ol;Benzeneethanol, 4-ethoxy-beta,beta-dimethyl-;4-ethoxy-beta,beta-dimethylbenzeneethanol;PENA;p-ethoxyneophyl alcohol;4-ethoxyneophyl alcohol;2-(4-ethoxyphenyl)-2-methyl-1-propanol;2-(4-ethoxyphenyl)-2-methyl-propan-1-ol;SCHEMBL7749333;CHEBI:39350;DTXSID60232401;MFCD07787279;AKOS006346495;2,2-dimethyl-2-(4-ethoxyphenyl)ethanol;AC-15259;AS-63625;METHYL6-BROMOQUINOLINE-2-CARBOXYLATE;CS-0299385;E0730;FT-0651977;D90559;EN300-1858048;A840587;J-505972;Q27119828

Chemical Property of 2-(4-Ethoxyphenyl)-2-methylpropan-1-ol

Chemical Property:

• Vapor Pressure: 0.000729mmHg at 25°C
• Melting Point: 48 ºC
• Boiling Point: 294.6 °C at 760 mmHg
• PKA: 15.01±0.10(Predicted)
• Flash Point: 117.9 °C
• PSA: 29.46000
• Density: 1 g/cm³
• LogP: 2.35520
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 194.130679813
• Heavy Atom Count: 14
• Complexity: 158

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Ethoxyphenyl)-2-methylpropanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,F
• Hazard Codes: Xi,F

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)C(C)(C)CO

Technology Process of 2-(4-Ethoxyphenyl)-2-methylpropan-1-ol

There total 5 articles about 2-(4-Ethoxyphenyl)-2-methylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.2%

2-(4-ethoxyphenyl)-2-methylpropionic acid (86521-64-4) → 2-(4-ethoxyphenyl)-2,2-dimethylethanol (83493-63-4)

Guidance literature:

With potassium borohydride; zinc(II) chloride; In ethanol; at 30 - 60 ℃; Temperature; Solvent; Reagent/catalyst;

Reference yield: 80.0%

2-(3-chloro-4-ethoxyphenyl)-2-methylpropyl acetate → 2-(4-ethoxyphenyl)-2,2-dimethylethanol (83493-63-4)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; potassium hydroxide; In methanol; water; at 70 ℃; for 18h; under 3800.26 Torr;

Reference yield: 75.0%

C17H25BrO3 → 2-(4-ethoxyphenyl)-2,2-dimethylethanol (83493-63-4)

Guidance literature:

C₁₇H₂₅BrO₃; With zinc; In toluene; Reflux;

With aluminum (III) chloride; sodium tetrahydroborate; at 20 ℃; for 6h;

upstream raw materials:

2-(4-ethoxyphenyl)-2-methylpropionic acid

1-chloro-2-ethoxybenzene

Downstream raw materials:

2-(4-ethoxyphenyl)-2-methylpropionic acid

etofenprox

5-{4-[2-(4-Ethoxy-phenyl)-2-methyl-propoxy]-benzyl}-thiazolidine-2,4-dione

2-Chloro-3-{4-[2-(4-ethoxy-phenyl)-2-methyl-propoxy]-phenyl}-propionic acid methyl ester

Refernces

• 1、 -. "Method for manufacturing Etofenprox intermediate". . . Retrieved 2019/12/25.