Bicyclol

Base Information Edit

Chemical Name:Bicyclol
CAS No.:118159-48-1
Deprecated CAS:428876-70-4
Molecular Formula:C₁₉H₁₈O₉
Molecular Weight:390.347
Hs Code.:
European Community (EC) Number:633-021-4
UNII:9734122TH2
DSSTox Substance ID:DTXSID30152026
Nikkaji Number:J2.598.891D
Wikidata:Q27271958
Metabolomics Workbench ID:138149
ChEMBL ID:CHEMBL482035
Mol file:118159-48-1.mol

Synonyms:4,4'-bi-(1,3-benzodioxole)-5-carboxylic acid, 5'-(hydroxymethyl)-7,7'-dimethoxy-, methyl ester;6-methoxycarbonyl-6'-hydroxymethyl-2,3,2',3'-bis(methylenedioxy)-4,4'-dimethoxybiphenyl;bicyclol

Suppliers and Price of Bicyclol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Bicyclol
10mg
$ 100.00

Sigma-Aldrich
Bicyclol ≥98% (HPLC)
25mg
$ 336.00

Sigma-Aldrich
Bicyclol ≥98% (HPLC)
5mg
$ 87.00

Matrix Scientific
Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate 95+%
1g
$ 4200.00

Matrix Scientific
Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate 95+%
250mg
$ 1890.00

CSNpharm
Bicyclol
10mg
$ 96.00

CSNpharm
Bicyclol
5mg
$ 58.00

CSNpharm
Bicyclol
25mg
$ 211.00

CSNpharm
Bicyclol
50mg
$ 403.00

Crysdot
Bicyclol 98+%
50mg
$ 298.00

Total 11 raw suppliers

Chemical Property of Bicyclol Edit

Chemical Property:

Boiling Point:608.1±55.0 °C(Predicted)
PKA:13.85±0.10(Predicted)
PSA：101.91000
Density:1.410±0.06 g/cm3(Predicted)
LogP:2.10710
Storage Temp.:2-8°C
Solubility.:DMSO: >10mg/mL
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:390.09508215
Heavy Atom Count:28
Complexity:558

Purity/Quality:

99% ^*data from raw suppliers

Bicyclol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:N
Statements: 50/53
Safety Statements: 60-61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C2C(=C(C(=C1)CO)C3=C4C(=C(C=C3C(=O)OC)OC)OCO4)OCO2
Recent ClinicalTrials:Bicyclol in the Treatment of Antineoplastic Drug-induced Liver Injury.
Description Bicyclol is a hepatoprotective agent. It has antiviral activity against hepatitis B (HBV), reducing viral DNA and the secretion of the HBV antigens HBsAg and HBeAg by 59 and 35%, respectively, in infected 2.2.15 HepG2 cells. In vivo, bicyclol reduces duck HBV (DHBV) DNA in DHBV-infected ducks at doses ≥0.4 g/kg. It also reduces the expression of TNF-α and the accumulation of lymphocytes in the liver in a mouse model of liver injury induced by concanavalin A . Oral administration of bicyclol prior to injection of diethylnitrosamine (DEN) and phenobarbital (PB; Item Nos. 9001494 | 20987) prevents formation of DEN/PB-induced hepatocellular carcinomas. It also reduces liver fibrosis in a rat model of bile duct ligation-induced hepatic fibrosis.
Uses Bicyclol is a novel hepatoprotectant shown to protect against liver injury by inducing Hsps, including Hsp27 and Hsp 70; Anti-inflammatory activity.

Technology Process of Bicyclol

There total 9 articles about Bicyclol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%