Technology Process of (E)-methyl 7,7'-dimethoxy-5'-(3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl)-(4,4'-bibenzo[d][1,3]dioxole)-5-carboxylate
There total 5 articles about (E)-methyl 7,7'-dimethoxy-5'-(3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl)-(4,4'-bibenzo[d][1,3]dioxole)-5-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C
2: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 20 °C
3: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C
4: boron trifluoride diethyl etherate / 1,4-dioxane / 115 °C / Inert atmosphere
With
dmap; sodium tetrahydroborate; boron trifluoride diethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
4: Claisen-Schmidt reaction;
DOI:10.1016/j.bmc.2012.02.050
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 3 h / Reflux
2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C
3: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 20 °C
4: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C
5: boron trifluoride diethyl etherate / 1,4-dioxane / 115 °C / Inert atmosphere
With
dmap; sodium tetrahydroborate; boron trifluoride diethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
5: Claisen-Schmidt reaction;
DOI:10.1016/j.bmc.2012.02.050
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C
2: boron trifluoride diethyl etherate / 1,4-dioxane / 115 °C / Inert atmosphere
With
boron trifluoride diethyl etherate; pyridinium chlorochromate;
In
1,4-dioxane; dichloromethane;
2: Claisen-Schmidt reaction;
DOI:10.1016/j.bmc.2012.02.050