3-Phenylpropanehydrazide

Base Information

• Chemical Name: 3-Phenylpropanehydrazide
• CAS No.: 3538-68-9
• Molecular Formula: C9H12N2O
• Molecular Weight: 164.207
• Hs Code.: 2928000090
• European Community (EC) Number: 809-055-2
• NSC Number: 67600
• DSSTox Substance ID: DTXSID50290237
• Nikkaji Number: J2.833.010C
• Wikidata: Q82027854
• Mol file: 3538-68-9.mol

Synonyms:3-phenylpropanehydrazide;3538-68-9;3-Phenyl-propionic acid hydrazide;3-phenylpropanohydrazide;Benzenepropanoicacid, hydrazide;3-Phenylpropionic acid hydrazide;3-phenylPropanoic acid hydrazide;Benzenepropanoic acid hydrazide;NSC67600;3-PHENYL-PROPIONICACIDHYDRAZIDE;dihydrocinnamic hydrazide;TimTec1_000994;3-phenyl-propionic hydrazide;NCIOpen2_000222;Oprea1_209591;SCHEMBL967387;DTXSID50290237;HMS1536N04;3-?Phenyl-?propionic Acid Hydrazide;BBL015565;MFCD00157933;NSC 67600;NSC-67600;STK097159;AKOS000139673;SB85919;NCGC00174901-01;AS-11238;BB 0262532;CS-0046856;FT-0678489;EN300-62044;W15768;A912307;BRD-K64141471-001-01-8

Chemical Property of 3-Phenylpropanehydrazide

Chemical Property:

• Vapor Pressure: 8.7E-06mmHg at 25°C
• Refractive Index: 1.554
• Boiling Point: 373.8 °C at 760 mmHg
• Flash Point: 179.9 °C
• PSA: 55.12000
• Density: 1.106 g/cm³
• LogP: 1.70030
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 164.094963011
• Heavy Atom Count: 12
• Complexity: 142

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Phenyl-propionic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCC(=O)NN
• Uses: 3-?Phenyl-?propionic Acid Hydrazide is a reactant used to prepare trisubstituted 1,2,4-triazoles as potent human ghrelin receptor (GHS-R1a) ligands. It is also used as an intermediate to synthesisze oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors.

Technology Process of 3-Phenylpropanehydrazide

There total 20 articles about 3-Phenylpropanehydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl dihydrocinnamate (2021-28-5) → 3-phenylpropanehydrazide (3538-68-9)

Guidance literature:

With hydrazine hydrate; In methanol; for 72h; Ambient temperature;

Reference yield: 92.0%

3-phenylpropanoic acid methyl ester (103-25-3) → 3-phenylpropanehydrazide (3538-68-9)

Guidance literature:

With hydrazine hydrate; at 110 - 120 ℃;

DOI:10.1039/b110414d

Reference yield: 82.0%

N-(4-methoxyphenyl)-3-phenylpropionamide (97754-31-9) → 3-phenylpropanehydrazide (3538-68-9) + 4-methoxy-aniline (104-94-9)

Guidance literature:

With ammonium iodide; hydrazine; In ethanol; at 80 ℃; for 48h;

upstream raw materials:

ethanol

ethyl dihydrocinnamate

(E)-3-phenylacryloylhydrazide

3-hydrazino-3-phenyl-propionic acid hydrazide

Downstream raw materials:

5,5'-diphenethyl-2,3,2',3'-tetrahydro-3,3'-(2-oxa-propane-1,3-diyl)-bis-[1,3,4]oxadiazole

5-Oxo-2-phenethyl-5H-[1,3,4]oxadiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester

2-[(5-Phenethyl-[1,3,4]oxadiazol-2-ylamino)-methylene]-malonic acid diethyl ester

N'-[(1E)-4-hydroxy-3-methoxy-5-nitrobenzylidene]-3-phenylpropanohydrazide

Refernces

• 1、 Gavara, Laurent,Legru, Alice,Verdirosa, Federica,Sevaille, Laurent,Nauton, Lionel,Corsica, Giuseppina,Mercuri, Paola Sandra,Sannio, Filomena,Feller, Georges,Coulon, Rémi,De Luca, Filomena,Cerboni, Giulia,Tanfoni, Silvia,Chelini, Giulia,Galleni, Moreno,Docquier, Jean-Denis,Hernandez, Jean-Fran?ois. "4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors". supporting information. . Retrieved 2021/06/15.
• 2、 Apayd?n, ?a?la Begüm,Cesur, Nesrin,Stevaert, Annelies,Naesens, Lieve,Cesur, Zafer. "Synthesis and anti-coronavirus activity of a series of 1-thia-4-azaspiro[4.5]decan-3-one derivatives". . . Retrieved 2019/06/05.