Methyl 2-chloro-5-Methylisonicotinate

Base Information

• Chemical Name: Methyl 2-chloro-5-Methylisonicotinate
• CAS No.: 787596-43-4
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol file: 787596-43-4.mol

Synonyms:Methyl 2-chloro-5-Methylisonicotinate

Chemical Property of Methyl 2-chloro-5-Methylisonicotinate

Chemical Property:

• PSA: 39.19000
• LogP: 1.83000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% purity ^*data from raw suppliers

2-Chloro-5-methyl-isonicotinicacidmethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 2-chloro-5-Methylisonicotinate

There total 11 articles about Methyl 2-chloro-5-Methylisonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 2-chloro-5-methylisonicotinic acid (951030-56-1) → methyl 2-chloro-5-methylisonicotinate (787596-43-4)

Guidance literature:

2-chloro-5-methylisonicotinic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

methanol; In dichloromethane; for 1h;

Reference yield: 48.0%

methyl 5-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate → methyl 2-chloro-5-methylisonicotinate (787596-43-4)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 16h;

Reference yield:

methyl 5-bromo-2-chloropyridine-4-carboxylate (886365-28-2) + trimethylaluminum (75-24-1) → methyl 2-chloro-5-methylisonicotinate (787596-43-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 80 ℃; for 6h;

upstream raw materials:

dihydroxy-methyl-borane

methyl 5-bromo-2-chloropyridine-4-carboxylate

methanol

2-chloro-5-methylisonicotinic acid

Refernces

• 1、 -. "INHIBITORS OF KEAP1-Nrf2 PROTEIN-PROTEIN INTERACTION". . . Retrieved 2020/03/01.
• 2、 -. "PROCESS FOR PREPARING 1-ARYLSULFONYL-PYRROLIDINE-2-CARBOXAMIDE TRANSIENT RECEPTOR POTENTIAL CHANNEL ANTAGONIST COMPOUNDS AND CRYSTALLINE FORMS THEREOF". Paragraph 0429; 0433-0438. . Retrieved 2019/09/12.