alpha, oMega-Dipropionic acid triethylene glycol

Base Information

• Chemical Name: alpha, oMega-Dipropionic acid triethylene glycol
• CAS No.: 31127-85-2
• Molecular Formula: C12H22O8
• Molecular Weight: 294.302
• Hs Code.: 2918999090
• Mol file: 31127-85-2.mol

Synonyms:alpha, oMega-Dipropionic acid triethylene glycol;HOOC-PEG3-COOH;α,ω-Dipropionic acid triethylene glycol;4,7,10,13-Tetraoxahexadecanedioic acid;Bis-PEG4-acid;Bis-PEG5-acid

Chemical Property of alpha, oMega-Dipropionic acid triethylene glycol

Chemical Property:

• Boiling Point: 483.7±45.0 °C(Predicted)
• PKA: 3.97±0.10(Predicted)
• PSA: 111.52000
• Density: 1.219±0.06 g/cm3(Predicted)
• LogP: 0.00220
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

α,ω-dipropionicacidtriethyleneglycol min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Bis-PEG4-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Technology Process of alpha, oMega-Dipropionic acid triethylene glycol

There total 5 articles about alpha, oMega-Dipropionic acid triethylene glycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formic acid (64-18-6) + di-tert-butyl 4,7,10,13-tetraoxahexadecane-1,16-dioate → 4,7,10,13-tetraoxahexadecane-1,16-dioic acid (31127-85-2)

Guidance literature:

at 20 ℃; for 24h;

Reference yield:

α,ω-di(cyanoethylene)triethylene tetraoxide (57741-46-5) → 4,7,10,13-tetraoxahexadecane-1,16-dioic acid (31127-85-2)

Guidance literature:

With hydrogenchloride; for 0.0833333h; Heating;

DOI:10.1246/bcsj.61.2443

Reference yield:

2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 4,7,10,13-tetraoxahexadecane-1,16-dioic acid (31127-85-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / benzene / 1 h / Ambient temperature

2: 12M hydrochloric acid / 0.08 h / Heating

With hydrogenchloride; potassium hydroxide; In benzene;

DOI:10.1246/bcsj.61.2443

upstream raw materials:

4,7,10,13-tetraoxa-hexadecanedioic acid diethyl ester

α,ω-di(cyanoethylene)triethylene tetraoxide

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

formic acid

Downstream raw materials:

C₃₀H₃₂I₆N₄O₁₂

C₃₂H₃₆I₆N₄O₁₂

C₃₆H₄₄I₆N₄O₁₂

Iodoxamic acid

Refernces

• 1、 -. "PEPTIDIC LINKERS AND CRYPTOPHYCIN CONJUGATES, USEFUL IN THERAPY, AND THEIR PREPARATION". . . Retrieved 2018/12/02.
• 2、 Felder,Pitre,Fumagalli,Lorenzotti. "Radiopaque contrast media. XXIV. Synthesis and structure activity relationships of new hexaiodinated radiopaque compounds". . p. 912 - 924. Retrieved 2007/10/06.