N-(bromoacetyl)homoveratrylamine

Base Information

• Chemical Name: N-(bromoacetyl)homoveratrylamine
• CAS No.: 56997-75-2
• Molecular Formula: C12H16 Br N O3
• Molecular Weight: 302.16
• Mol file: 56997-75-2.mol

Synonyms:N-(bromoacetyl)homoveratrylamine

Chemical Property of N-(bromoacetyl)homoveratrylamine

Chemical Property:

• Vapor Pressure: 3.11E-08mmHg at 25°C
• Boiling Point: 448.4°Cat760mmHg
• Flash Point: 225°C
• PSA: 51.05000
• Density: 1.358g/cm³
• LogP: 2.59770

Purity/Quality:

2-Bromo-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(bromoacetyl)homoveratrylamine

There total 6 articles about N-(bromoacetyl)homoveratrylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + bromoacetic acid (79-08-3) → N-(3,4-dimethoxyphenethyl)-α-bromoacetamide (56997-75-2)

Guidance literature:

With dacarbazine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.12.060

Reference yield:

2-nitro-1-(3,4-dimethoxyphenyl)ethanol (39220-86-5) → N-(3,4-dimethoxyphenethyl)-α-bromoacetamide (56997-75-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride

2: potassium carbonate

With lithium aluminium tetrahydride; potassium carbonate;

DOI:10.1002/asia.201403361

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → N-(3,4-dimethoxyphenethyl)-α-bromoacetamide (56997-75-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ethylenediamine diacetic acid

2: lithium aluminium tetrahydride

3: potassium carbonate

With lithium aluminium tetrahydride; potassium carbonate; ethylenediamine diacetic acid;

DOI:10.1002/asia.201403361

upstream raw materials:

2-(3,4-dimethoxyphenyl)-ethylamine

2-Bromoacetyl bromide

bromoacetic acid

2-bromoacetyl chloride

Downstream raw materials:

N-(3,4-Dimethoxy-β-phenylaethyl)-acetoxyacetamid

N-hydroxy-4-{[(3,4-dimethoxyphenethylcarbamoylmethyl)amino]methyl}benzamide

diethyl [2-(2-(3,4-dimethoxyphenyl)ethylamino)-2-oxoethyl]phosphonate

C₂₂H₃₁NO₈

Refernces

• 1、 Tangdenpaisal, Kassrin,Worayuthakarn, Rattana,Karnkla, Supatra,Ploypradith, Poonsakdi,Intachote, Pakamas,Sengsai, Suchada,Saimanee, Busakorn,Ruchirawat, Somsak,Chittchang, Montakarn. "Designing new analogs for streamlining the structure of cytotoxic lamellarin natural products". . p. 925 - 937. Retrieved 2015/03/31.
• 2、 McKeown, Stephen C.,Hall, Adrian,Blunt, Richard,Brown, Susan H.,Chessell, Iain P.,Chowdhury, Anita,Giblin, Gerard M.P.,Healy, Mark P.,Johnson, Matthew R.,Lorthioir, Olivier,Michel, Anton D.,Naylor, Alan,Lewell, Xiao,Roman, Shilina,Watson, Stephen P.,Winchester, Wendy J.,Wilson, Richard J.. "Identification of novel glycine sulfonamide antagonists for the EP1 receptor". . p. 1750 - 1754. Retrieved 2007/10/03.